GLYCAM1

glycosylation dependent cell adhesion molecule-1
Identifiers
Symbol GLYCAM1
Entrez 644076
HUGO 18023
RefSeq XM_927461
UniProt Q8IVK1
Other data
Locus Chr. 12 q13.2

Glycosylation-dependent cell adhesion molecule-1 (GLYCAM1) is a proteoglycan ligand expressed on cells of the high endothelial venules in lymphoid tissues. It is the ligand for the receptor L-selectin allowing for naive lymphocytes to exit the bloodstream into lymphoid tissues.[1][2] GLYCAM1 binds to L-selectin by presenting one or more O-linked carbohydrates to the lectin domain of the leukocyte cell surface selectin. Data suggests that GLYCAM1 is a hormone-regulated milk protein that is part of the milk mucin complex.[3]

GlyCAM-1 is expressed exclusively on high endothelial venules. It is unclear how GlyCAM-1 is attached to the membrane as it lacks a transmembrane region.[1]

References

  1. 1 2 Imhof, Beat A.; Dunon, Dominique. Leukocyte Migration and Adhesion. pp. 345–416. doi:10.1016/s0065-2776(08)60623-9.
  2. ↑ "Identification of a soluble form of a ligand for the lymphocyte homing receptor". The Journal of Experimental Medicine. 176 (5): 1415–1419. 1992 Nov 1. PMC 2119429. PMID 1383387. Check date values in: |date= (help)
  3. ↑ Dowbenko D, Kikuta A, Fennie C, Gillett N, Lasky LA (August 1993). "Glycosylation-dependent cell adhesion molecule 1 (GlyCAM 1) mucin is expressed by lactating mammary gland epithelial cells and is present in milk". The Journal of Clinical Investigation. 92 (2): 952–60. doi:10.1172/JCI116671. PMC 294935. PMID 8349827.


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