GLCE

GLCE
Identifiers
AliasesGLCE, HSEPI, glucuronic acid epimerase
External IDsMGI: 2136405 HomoloGene: 14111 GeneCards: GLCE
Gene location (Human)
Chr.Chromosome 15 (human)[1]
Band15q23Start69,160,584 bp[1]
End69,272,217 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

26035

93683

Ensembl

ENSG00000138604

ENSMUSG00000032252

UniProt

O94923

Q9EPS3

RefSeq (mRNA)

NM_015554
NM_001324091
NM_001324092
NM_001324093
NM_001324094

NM_033320

RefSeq (protein)

NP_001311020
NP_001311021
NP_001311022
NP_001311023
NP_056369

NP_201577

Location (UCSC)Chr 15: 69.16 – 69.27 MbChr 9: 62.06 – 62.12 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

D-glucuronyl C5-epimerase is an enzyme that in humans is encoded by the GLCE gene.[5][6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000138604 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032252 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Ghiselli G, Agrawal A (Aug 2005). "The human D-glucuronyl C5-epimerase gene is transcriptionally activated through the β-catenin–TCF4 pathway". Biochem J. 390 (Pt 2): 493–9. doi:10.1042/BJ20050152. PMC 1198929. PMID 15853773.
  6. ↑ "Entrez Gene: GLCE glucuronic acid epimerase".

Further reading

  • Grigorieva E, Eshchenko T, Rykova VI, et al. (2008). "Decreased expression of human D-glucuronyl C5-epimerase in breast cancer". Int. J. Cancer. 122 (5): 1172–6. doi:10.1002/ijc.23203. PMID 17985344.
  • Hagner-McWhirter A, Li JP, Oscarson S, Lindahl U (2004). "Irreversible glucuronyl C5-epimerization in the biosynthesis of heparan sulfate". J. Biol. Chem. 279 (15): 14631–8. doi:10.1074/jbc.M313760200. PMID 14718527.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Crawford BE, Olson SK, Esko JD, Pinhal MA (2001). "Cloning, Golgi localization, and enzyme activity of the full-length heparin/heparan sulfate-glucuronic acid C5-epimerase". J. Biol. Chem. 276 (24): 21538–43. doi:10.1074/jbc.M100880200. PMID 11279150.
  • Li JP, Gong F, El Darwish K, et al. (2001). "Characterization of the D-glucuronyl C5-epimerase involved in the biosynthesis of heparin and heparan sulfate". J. Biol. Chem. 276 (23): 20069–77. doi:10.1074/jbc.M011783200. PMID 11274177.
  • Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.
  • Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.


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