GKN1

GKN1
Identifiers
AliasesGKN1, AMP18, BRICD1, CA11, FOV, foveolin, gastrokine 1
External IDsMGI: 1913533 HomoloGene: 10487 GeneCards: GKN1
Gene location (Human)
Chr.Chromosome 2 (human)[1]
Band2p13.3Start68,974,573 bp[1]
End68,980,974 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

56287

66283

Ensembl

ENSG00000169605

ENSMUSG00000030050

UniProt

Q9NS71

Q9CR36

RefSeq (mRNA)

NM_019617

NM_025466

RefSeq (protein)

NP_062563

NP_079742

Location (UCSC)Chr 2: 68.97 – 68.98 MbChr 6: 87.35 – 87.35 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Gastrokine-1 is a protein that in humans is encoded by the GKN1 gene.[5][6][7]

The protein encoded by this gene is found to be down-regulated in human gastric cancer tissue as compared to normal gastric mucosa.[7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000169605 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030050 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Martin TE, Powell CT, Wang Z, Bhattacharyya S, Walsh-Reitz MM, Agarwal K, Toback FG (Jul 2003). "A novel mitogenic protein that is highly expressed in cells of the gastric antrum mucosa". Am J Physiol Gastrointest Liver Physiol. 285 (2): G332–43. doi:10.1152/ajpgi.00453.2002. PMID 12851218.
  6. ↑ Shiozaki K, Nakamori S, Tsujie M, Okami J, Yamamoto H, Nagano H, Dono K, Umeshita K, Sakon M, Furukawa H, Hiratsuka M, Kasugai T, Ishiguro S, Monden M (Sep 2001). "Human stomach-specific gene, CA11, is down-regulated in gastric cancer". Int J Oncol. 19 (4): 701–7. doi:10.3892/ijo.19.4.701. PMID 11562744.
  7. 1 2 "Entrez Gene: GKN1 gastrokine 1".

Further reading

  • Yoshikawa Y, Mukai H, Hino F, et al. (2000). "Isolation of two novel genes, down-regulated in gastric cancer". Jpn. J. Cancer Res. 91 (5): 459–63. doi:10.1111/j.1349-7006.2000.tb00967.x. PMID 10835488.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Westley BR, Griffin SM, May FE (2005). "Interaction between TFF1, a gastric tumor suppressor trefoil protein, and TFIZ1, a brichos domain-containing protein with homology to SP-C". Biochemistry. 44 (22): 7967–75. doi:10.1021/bi047287n. PMID 15924415.
  • Walsh-Reitz MM, Huang EF, Musch MW, et al. (2005). "AMP-18 protects barrier function of colonic epithelial cells: role of tight junction proteins". Am. J. Physiol. Gastrointest. Liver Physiol. 289 (1): G163–71. doi:10.1152/ajpgi.00013.2005. PMC 1444946. PMID 15961882.
  • Nardone G, Rippa E, Martin G, et al. (2007). "Gastrokine 1 expression in patients with and without Helicobacter pylori infection". Digestive and Liver Disease. 39 (2): 122–9. doi:10.1016/j.dld.2006.09.017. PMID 17092786.


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