GIMAP4

GIMAP4
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesGIMAP4, IAN-1, IAN1, IMAP4, MSTP062, GTPase, IMAP family member 4
External IDsMGI: 1349656 HomoloGene: 75084 GeneCards: GIMAP4
Gene location (Human)
Chr.Chromosome 7 (human)[1]
Band7q36.1Start150,567,277 bp[1]
End150,573,955 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

55303

107526

Ensembl

ENSG00000133574

ENSMUSG00000054435

UniProt

Q9NUV9

Q99JY3

RefSeq (mRNA)

NM_018326
NM_001363532

NM_001243199
NM_001243200
NM_001243201
NM_174990
NM_175048

RefSeq (protein)

NP_060796
NP_001350461

NP_001230128
NP_001230129
NP_001230130
NP_778155
NP_778213

Location (UCSC)Chr 7: 150.57 – 150.57 MbChr 6: 48.68 – 48.69 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

GTPase IMAP family member 4 is an enzyme that in humans is encoded by the GIMAP4 gene.[5][6][7]

This gene encodes a protein belonging to the GTP-binding superfamily and to the immuno-associated nucleotide (IAN) subfamily of nucleotide-binding proteins. The encoded protein of this gene may be negatively regulated by T-cell acute lymphocytic leukemia 1 (TAL1). In humans, the IAN subfamily genes are located in a cluster at 7q36.1.[7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000133574 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000054435 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Krucken J, Schroetel RM, Muller IU, Saidani N, Marinovski P, Benten WP, Stamm O, Wunderlich F (Oct 2004). "Comparative analysis of the human gimap gene cluster encoding a novel GTPase family". Gene. 341: 291–304. doi:10.1016/j.gene.2004.07.005. PMID 15474311.
  6. ↑ Filen JJ, Filen S, Moulder R, Tuomela S, Ahlfors H, West A, Kouvonen P, Kantola S, Bjorkman M, Katajamaa M, Rasool O, Nyman TA, Lahesmaa R (Jan 2009). "Quantitative proteomics reveals GIMAP family proteins 1 and 4 to be differentially regulated during human T helper cell differentiation". Mol Cell Proteomics. 8 (1): 32–44. doi:10.1074/mcp.M800139-MCP200. PMC 2621005. PMID 18701445.
  7. 1 2 "Entrez Gene: GIMAP4 GTPase, IMAP family member 4".

Further reading

  • Dominguez O, Ashhab Y, Sabater L, et al. (1999). "Cloning of ARE-containing genes by AU-motif-directed display". Genomics. 54 (2): 278–86. doi:10.1006/geno.1998.5548. PMID 9828130.
  • Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
  • Stamm O, Krücken J, Schmitt-Wrede HP, et al. (2002). "Human ortholog to mouse gene imap38 encoding an ER-localizable G-protein belongs to a gene family clustered on chromosome 7q32-36". Gene. 282 (1–2): 159–67. doi:10.1016/S0378-1119(01)00837-X. PMID 11814688.
  • Cambot M, Aresta S, Kahn-Perlès B, et al. (2002). "Human immune associated nucleotide 1: a member of a new guanosine triphosphatase family expressed in resting T and B cells". Blood. 99 (9): 3293–301. doi:10.1182/blood.V99.9.3293. PMID 11964296.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Nitta T, Nasreen M, Seike T, et al. (2006). "IAN family critically regulates survival and development of T lymphocytes". PLoS Biol. 4 (4): e103. doi:10.1371/journal.pbio.0040103. PMC 1393758. PMID 16509771.


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