GGPS1

GGPS1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesGGPS1, GGPPS, GGPPS1, geranylgeranyl diphosphate synthase 1
External IDsMGI: 1341724 HomoloGene: 31267 GeneCards: GGPS1
EC number2.5.1.1
Gene location (Human)
Chr.Chromosome 1 (human)[1]
Band1q42.3Start235,327,350 bp[1]
End235,344,532 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

9453

14593

Ensembl

ENSG00000152904

ENSMUSG00000021302

UniProt

O95749

Q9WTN0

RefSeq (mRNA)

NM_001037277
NM_001037278
NM_004837

RefSeq (protein)

NP_001032354
NP_001032354.1

Location (UCSC)Chr 1: 235.33 – 235.34 MbChr 13: 14.05 – 14.06 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Geranylgeranyl pyrophosphate synthase is an enzyme that in humans is encoded by the GGPS1 gene.[5][6][7]

Function

This gene is a member of the prenyltransferase family and encodes a protein with geranylgeranyl diphosphate (GGPP) synthase activity. The enzyme catalyzes the synthesis of GGPP from farnesyl diphosphate and isopentenyl diphosphate. GGPP is an important molecule responsible for the C20-prenylation of proteins and for the regulation of a nuclear hormone receptor. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[7]

Much like its homolog farnesyl diphosphate synthase, GGPS1 is inhibited by bisphosphonate compounds.[8]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000152904 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021302 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Ericsson J, Greene JM, Carter KC, Shell BK, Duan DR, Florence C, Edwards PA (September 1998). "Human geranylgeranyl diphosphate synthase: isolation of the cDNA, chromosomal mapping and tissue expression". Journal of Lipid Research. 39 (9): 1731–9. PMID 9741684.
  6. ↑ Kainou T, Kawamura K, Tanaka K, Matsuda H, Kawamukai M (March 1999). "Identification of the GGPS1 genes encoding geranylgeranyl diphosphate synthases from mouse and human". Biochimica et Biophysica Acta. 1437 (3): 333–40. doi:10.1016/S1388-1981(99)00028-1. PMID 10101267.
  7. 1 2 "Entrez Gene: GGPS1 geranylgeranyl diphosphate synthase 1".
  8. ↑ Wiemer AJ, Wiemer DF, Hohl RJ (December 2011). "Geranylgeranyl diphosphate synthase: an emerging therapeutic target". Clinical Pharmacology and Therapeutics. 90 (6): 804–12. doi:10.1038/clpt.2011.215. PMID 22048229.

Further reading

  • Ericsson J, Runquist M, Thelin A, Andersson M, Chojnacki T, Dallner G (January 1993). "Distribution of prenyltransferases in rat tissues. Evidence for a cytosolic all-trans-geranylgeranyl diphosphate synthase". The Journal of Biological Chemistry. 268 (2): 832–8. PMID 8419360.
  • Kuzuguchi T, Morita Y, Sagami I, Sagami H, Ogura K (February 1999). "Human geranylgeranyl diphosphate synthase. cDNA cloning and expression". The Journal of Biological Chemistry. 274 (9): 5888–94. doi:10.1074/jbc.274.9.5888. PMID 10026212.
  • Hu RM, Han ZG, Song HD, Peng YD, Huang QH, Ren SX, Gu YJ, Huang CH, Li YB, Jiang CL, Fu G, Zhang QH, Gu BW, Dai M, Mao YF, Gao GF, Rong R, Ye M, Zhou J, Xu SH, Gu J, Shi JX, Jin WR, Zhang CK, Wu TM, Huang GY, Chen Z, Chen MD, Chen JL (August 2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proceedings of the National Academy of Sciences of the United States of America. 97 (17): 9543–8. doi:10.1073/pnas.160270997. PMC 16901. PMID 10931946.
  • Bommel H, Xie G, Rossoll W, Wiese S, Jablonka S, Boehm T, Sendtner M (November 2002). "Missense mutation in the tubulin-specific chaperone E (Tbce) gene in the mouse mutant progressive motor neuronopathy, a model of human motoneuron disease". The Journal of Cell Biology. 159 (4): 563–9. doi:10.1083/jcb.200208001. PMC 2173089. PMID 12446740.
  • Kavanagh KL, Dunford JE, Bunkoczi G, Russell RG, Oppermann U (August 2006). "The crystal structure of human geranylgeranyl pyrophosphate synthase reveals a novel hexameric arrangement and inhibitory product binding". The Journal of Biological Chemistry. 281 (31): 22004–12. doi:10.1074/jbc.M602603200. PMID 16698791.
  • Ma J, Dempsey AA, Stamatiou D, Marshall KW, Liew CC (March 2007). "Identifying leukocyte gene expression patterns associated with plasma lipid levels in human subjects". Atherosclerosis. 191 (1): 63–72. doi:10.1016/j.atherosclerosis.2006.05.032. PMID 16806233.
  • Raz T, Nardi V, Azam M, Cortes J, Daley GQ (September 2007). "Farnesyl transferase inhibitor resistance probed by target mutagenesis". Blood. 110 (6): 2102–9. doi:10.1182/blood-2006-12-064907. PMC 1976354. PMID 17536018.


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