GFI1B

GFI1B
Identifiers
AliasesGFI1B, BDPLT17, ZNF163B, growth factor independent 1B transcriptional repressor
External IDsMGI: 1276578 HomoloGene: 31223 GeneCards: GFI1B
Gene location (Human)
Chr.Chromosome 9 (human)[1]
Band9q34.13Start132,944,000 bp[1]
End132,991,687 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

8328

14582

Ensembl

ENSG00000165702

ENSMUSG00000026815

UniProt

Q5VTD9

O70237

RefSeq (mRNA)

NM_001135031
NM_004188

NM_001160406
NM_008114

RefSeq (protein)

NP_001128503
NP_004179

NP_001153878
NP_032140

Location (UCSC)Chr 9: 132.94 – 132.99 MbChr 2: 28.61 – 28.62 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Zinc finger protein Gfi-1b is a protein that in humans is encoded by the GFI1B gene.[5][6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000165702 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026815 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Rodel B, Wagner T, Zornig M, Niessing J, Moroy T (Feb 1999). "The human homologue (GFI1B) of the chicken GFI gene maps to chromosome 9q34.13-A locus frequently altered in hematopoietic diseases". Genomics. 54 (3): 580–2. doi:10.1006/geno.1998.5601. PMID 9878267.
  6. ↑ "Entrez Gene: GFI1B growth factor independent 1B (potential regulator of CDKN1A, translocated in CML)".

Further reading

  • Tong B, Grimes HL, Yang TY, et al. (1998). "The Gfi-1B proto-oncoprotein represses p21WAF1 and inhibits myeloid cell differentiation". Mol. Cell. Biol. 18 (5): 2462–73. PMC 110626. PMID 9566867.
  • Osawa M, Yamaguchi T, Nakamura Y, et al. (2002). "Erythroid expansion mediated by the Gfi-1B zinc finger protein: role in normal hematopoiesis". Blood. 100 (8): 2769–77. doi:10.1182/blood-2002-01-0182. PMID 12351384.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Huang DY, Kuo YY, Lai JS, et al. (2004). "GATA-1 and NF-Y cooperate to mediate erythroid-specific transcription of Gfi-1B gene". Nucleic Acids Res. 32 (13): 3935–46. doi:10.1093/nar/gkh719. PMC 506805. PMID 15280509.
  • Garçon L, Lacout C, Svinartchouk F, et al. (2005). "Gfi-1B plays a critical role in terminal differentiation of normal and transformed erythroid progenitor cells". Blood. 105 (4): 1448–55. doi:10.1182/blood-2003-11-4068. PMID 15507521.
  • Huang DY, Kuo YY, Chang ZF (2005). "GATA-1 mediates auto-regulation of Gfi-1B transcription in K562 cells". Nucleic Acids Res. 33 (16): 5331–42. doi:10.1093/nar/gki838. PMC 1226314. PMID 16177182.
  • Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
  • Xu W, Kee BL (2007). "Growth factor independent 1B (Gfi1b) is an E2A target gene that modulates Gata3 in T-cell lymphomas". Blood. 109 (10): 4406–14. doi:10.1182/blood-2006-08-043331. PMID 17272506.
  • Kuo YY, Chang ZF (2007). "GATA-1 and Gfi-1B interplay to regulate Bcl-xL transcription". Mol. Cell. Biol. 27 (12): 4261–72. doi:10.1128/MCB.02212-06. PMC 1900040. PMID 17420275.


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