GEFT

ARHGEF25
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesARHGEF25, GEFT, p63RhoGEF, Rho guanine nucleotide exchange factor 25
External IDsMGI: 1277173 HomoloGene: 32691 GeneCards: ARHGEF25
Gene location (Human)
Chr.Chromosome 12 (human)[1]
Band12q13.3Start57,610,180 bp[1]
End57,619,379 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

115557

52666

Ensembl

ENSG00000240771

ENSMUSG00000019467

UniProt

Q86VW2

Q9CWR0

RefSeq (mRNA)

NM_001111270
NM_133483
NM_182947
NM_001347933

NM_001166413
NM_028027
NM_001358557
NM_001358558

RefSeq (protein)

NP_001104740
NP_891992
NP_001334862

NP_001159885
NP_082303
NP_001345486
NP_001345487

Location (UCSC)Chr 12: 57.61 – 57.62 MbChr 10: 127.18 – 127.19 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

RAC/CDC42 exchange factor, also known as GEFT, is a human gene.[5]

Interactions

GEFT has been shown to interact with RHOA.[6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000240771 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000019467 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ "Entrez Gene: GEFT RAC/CDC42 exchange factor".
  6. ↑ Lutz S, Freichel-Blomquist A, Rümenapp U, Schmidt M, Jakobs KH, Wieland T (May 2004). "p63RhoGEF and GEFT are Rho-specific guanine nucleotide exchange factors encoded by the same gene". Naunyn Schmiedebergs Arch. Pharmacol. 369 (5): 540–6. doi:10.1007/s00210-004-0926-5. PMID 15069594.

Further reading

  • Lutz S, Shankaranarayanan A, Coco C, Ridilla M, Nance MR, Vettel C, Baltus D, Evelyn CR, Neubig RR, Wieland T, Tesmer JJ (2008). "Structure of Galphaq-p63RhoGEF-RhoA complex reveals a pathway for the activation of RhoA by GPCRs". Science. 318 (5858): 1923–7. doi:10.1126/science.1147554. PMID 18096806.
  • Bryan BA, Cai Y, Liu M (2006). "The Rho-family guanine nucleotide exchange factor GEFT enhances retinoic acid- and cAMP-induced neurite outgrowth". J. Neurosci. Res. 83 (7): 1151–9. doi:10.1002/jnr.20814. PMID 16496360.
  • Bryan BA, Mitchell DC, Zhao L, Ma W, Stafford LJ, Teng BB, Liu M (2006). "Modulation of muscle regeneration, myogenesis, and adipogenesis by the Rho family guanine nucleotide exchange factor GEFT". Mol. Cell. Biol. 25 (24): 11089–101. doi:10.1128/MCB.25.24.11089-11101.2005. PMC 1316953. PMID 16314529.
  • Lutz S, Freichel-Blomquist A, Yang Y, Rümenapp U, Jakobs KH, Schmidt M, Wieland T (2005). "The guanine nucleotide exchange factor p63RhoGEF, a specific link between Gq/11-coupled receptor signaling and RhoA". J. Biol. Chem. 280 (12): 11134–9. doi:10.1074/jbc.M411322200. PMID 15632174.
  • Bryan B, Kumar V, Stafford LJ, Cai Y, Wu G, Liu M (2004). "GEFT, a Rho family guanine nucleotide exchange factor, regulates neurite outgrowth and dendritic spine formation". J. Biol. Chem. 279 (44): 45824–32. doi:10.1074/jbc.M406216200. PMID 15322108.
  • Lutz S, Freichel-Blomquist A, Rümenapp U, Schmidt M, Jakobs KH, Wieland T (2004). "p63RhoGEF and GEFT are Rho-specific guanine nucleotide exchange factors encoded by the same gene". Naunyn Schmiedebergs Arch. Pharmacol. 369 (5): 540–6. doi:10.1007/s00210-004-0926-5. PMID 15069594.
  • Guo X, Stafford LJ, Bryan B, Xia C, Ma W, Wu X, Liu D, Songyang Z, Liu M (2003). "A Rac/Cdc42-specific exchange factor, GEFT, induces cell proliferation, transformation, and migration". J. Biol. Chem. 278 (15): 13207–15. doi:10.1074/jbc.M208896200. PMID 12547822.
  • Souchet M, Portales-Casamar E, Mazurais D, Schmidt S, Léger I, Javré JL, Robert P, Berrebi-Bertrand I, Bril A, Gout B, Debant A, Calmels TP (2002). "Human p63RhoGEF, a novel RhoA-specific guanine nucleotide exchange factor, is localized in cardiac sarcomere". J. Cell Sci. 115 (Pt 3): 629–40. PMID 11861769.


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