GATC (gene)

Glutamyl-tRNA(Gln) amidotransferase, subunit C homolog (bacterial) is a protein that in humans is encoded by the GATC gene.[1] The gene is also known as 15E1.2 and encodes part of an Glu-tRNA(Gln) amidotransferase enzyme.[1]

Model organisms

Model organisms have been used in the study of GATC function. A conditional knockout mouse line, called Gatctm1a(KOMP)Wtsi[6][7] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the Wellcome Trust Sanger Institute.[8][9][10]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[4][11] Twenty eight tests were carried out on mutant mice and two significant abnormalities were observed.[4] No homozygous mutant embryos were recorded during gestation and, in a separate study, no homozygous animals were observed at weaning. The remaining tests were carried out on adult heterozygous mutant animals but no further abnormalities were seen.[4]

References

  1. 1 2 "Glutamyl-tRNA(Gln) amidotransferase, subunit C homolog (bacterial)". Retrieved 2011-12-07.
  2. ↑ "Salmonella infection data for Gatc". Wellcome Trust Sanger Institute.
  3. ↑ "Citrobacter infection data for Gatc". Wellcome Trust Sanger Institute.
  4. 1 2 3 4 Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica. 88 (S248). doi:10.1111/j.1755-3768.2010.4142.x.
  5. ↑ Mouse Resources Portal, Wellcome Trust Sanger Institute.
  6. ↑ "International Knockout Mouse Consortium".
  7. ↑ "Mouse Genome Informatics".
  8. ↑ Skarnes, W. C.; Rosen, B.; West, A. P.; Koutsourakis, M.; Bushell, W.; Iyer, V.; Mujica, A. O.; Thomas, M.; Harrow, J.; Cox, T.; Jackson, D.; Severin, J.; Biggs, P.; Fu, J.; Nefedov, M.; De Jong, P. J.; Stewart, A. F.; Bradley, A. (2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–342. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.
  9. ↑ Dolgin E (June 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
  10. ↑ Collins FS, Rossant J, Wurst W (January 2007). "A mouse for all reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247.
  11. ↑ van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism". Genome Biol. 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC 3218837. PMID 21722353.

Further reading

  • Nagao, A.; Suzuki, T.; Katoh, T.; Sakaguchi, Y.; Suzuki, T. (2009). "Biogenesis of glutaminyl-mt tRNAGln in human mitochondria". Proceedings of the National Academy of Sciences. 106 (38): 16209–16214. doi:10.1073/pnas.0907602106. PMC 2752530. PMID 19805282.


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