GARNL1

RALGAPA1
Identifiers
AliasesRALGAPA1, GARNL1, GRIPE, RalGAPalpha1, TULIP1, p240, Ral GTPase activating protein catalytic alpha subunit 1
External IDsMGI: 1931050 HomoloGene: 84805 GeneCards: RALGAPA1
Gene location (Human)
Chr.Chromosome 14 (human)[1]
Band14q13.2Start35,538,352 bp[1]
End35,809,304 bp[1]
RNA expression pattern




More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

253959

56784

Ensembl

ENSG00000174373

ENSMUSG00000021027

UniProt

Q6GYQ0

Q6GYP7

RefSeq (mRNA)

NM_001003719
NM_001112714
NM_001286263
NM_019994

RefSeq (protein)

NP_001003719
NP_001106185
NP_001273192
NP_064378

Location (UCSC)Chr 14: 35.54 – 35.81 MbChr 12: 55.6 – 55.82 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

GTPase-activating Rap/Ran-GAP domain-like 1 is an enzyme that in humans is encoded by the RALGAPA1 gene.[5][6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000174373 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021027 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Shirakawa R, Fukai S, Kawato M, Higashi T, Kondo H, Ikeda T, Nakayama E, Okawa K, Nureki O, Kimura T, Kita T, Horiuchi H (Aug 2009). "Tuberous Sclerosis Tumor Suppressor Complex-like Complexes Act as GTPase-activating Proteins for Ral GTPases". J Biol Chem. 284 (32): 21580–8. doi:10.1074/jbc.M109.012112. PMC 2755882. PMID 19520869.
  6. ↑ "Entrez Gene: GARNL1 GTPase activating Rap/RanGAP domain-like 1".

Further reading

  • Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.
  • Heng JI, Tan SS (2003). "Cloning and characterization of GRIPE, a novel interacting partner of the transcription factor E12 in developing mouse forebrain". J. Biol. Chem. 277 (45): 43152–9. doi:10.1074/jbc.M204858200. PMID 12200424.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Swaminathan S, Kiendl F, Körner R, et al. (2004). "RanGAP1*SUMO1 is phosphorylated at the onset of mitosis and remains associated with RanBP2 upon NPC disassembly". J. Cell Biol. 164 (7): 965–71. doi:10.1083/jcb.200309126. PMC 2172064. PMID 15037602.
  • Fortna A, Kim Y, MacLaren E, et al. (2006). "Lineage-Specific Gene Duplication and Loss in Human and Great Ape Evolution". PLoS Biol. 2 (7): E207. doi:10.1371/journal.pbio.0020207. PMC 449870. PMID 15252450.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Schwarzbraun T, Vincent JB, Schumacher A, et al. (2005). "Cloning, genomic structure, and expression profiles of TULIP1 (GARNL1), a brain-expressed candidate gene for 14q13-linked neurological phenotypes, and its murine homologue". Genomics. 84 (3): 577–86. doi:10.1016/j.ygeno.2004.04.013. PMID 15498464.
  • Schmid EM, Ford MG, Burtey A, et al. (2007). "Role of the AP2 β-Appendage Hub in Recruiting Partners for Clathrin-Coated Vesicle Assembly". PLoS Biol. 4 (9): e262. doi:10.1371/journal.pbio.0040262. PMC 1540706. PMID 16903783.


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