GABA transporter type 3

GABA transporter type 3 (GAT3) uses sodium (Na+) electrochemical gradients to mediate uptake of GABA from the synaptic cleft by surrounding glial cells.[1]

Subtype-selective GAT3 inhibitors are known since 2015.[2]

See also

References

  1. ↑ Kandel ER, Schwartz JH, Jessell TM, Siegelbaum SA, Hudspeth AJ (2013). Principles of Neural Science (Fifth ed.). McGraw-Hill Companies. p. 296. ISBN 978-0-07-139011-8.
  2. ↑ Damgaard M, Al-Khawaja A, Vogensen SB, Jurik A, Sijm M, Lie ME, Bæk MI, Rosenthal E, Jensen AA, Ecker GF, Frølund B, Wellendorph P, Clausen RP (2015). "Identification of the First Highly Subtype-Selective Inhibitor of Human GABA Transporter GAT3". ACS Chem Neurosci. 6 (9): 1591–9. doi:10.1021/acschemneuro.5b00150. PMID 26154082.



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