G-CSF factor stem-loop destabilising element

G-CSF factor stem-loop destabilising element (SLDE)
Predicted secondary structure and sequence conservation of G-CSF_SLDE
Identifiers
Symbol G-CSF_SLDE
Rfam RF00183
Other data
RNA type Cis-reg
Domain(s) Eukaryota
SO 0000233
PDB structures PDBe

The G-CSF factor stem-loop destabilising element (SLDE) is an RNA element secreted by fibroblasts and endothelial cells in response to the inflammatory mediators interleukin-1 (IL-1) and tumour necrosis factor-alpha and by activated macrophages. The synthesis of G-CSF is regulated both transcriptionally and through control of mRNA stability. In unstimulated cells G-CSF mRNA is unstable but becomes stabilised in response to IL-1 or tumour necrosis factor alpha, and also in the case of monocytes and macrophages, in response to lipopolysaccharide. It is likely that the presence of the SLDE in the G-CSF mRNA contributes to the specificity of regulation of G-CSF mRNA and enhances the rate of shortening of the poly(A) tail.[1]

References

  1. ↑ Putland, RA; Sassinis TA; Harvey JS; Diamond P; Coles LS; Brown CY; Goodall GJ (2002). "RNA destabilization by the granulocyte colony-stimulating factor stem-loop destabilizing element involves a single stem-loop that promotes deadenylation". Mol Cell Biol. 22 (6): 1664&ndash, 1673. doi:10.1128/MCB.22.6.1664-1673.2002. PMC 135610. PMID 11865046.
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