Ferric-chelate reductase

ferric-chelate reductase
Identifiers
EC number 1.16.1.7
CAS number 122097-10-3
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO

In enzymology, a ferric-chelate reductase (EC 1.16.1.7) is an enzyme that catalyzes the chemical reaction

2 Fe(II) + NAD+ 2 Fe(III) + NADH + H+

Thus, the two substrates of this enzyme are Fe(II) and NAD+, whereas its 3 products are Fe(III), NADH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those oxidizing metal ion with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is Fe(II):NAD+ oxidoreductase. Other names in common use include ferric chelate reductase, iron chelate reductase, NADH:Fe3+-EDTA reductase, and NADH2:Fe3+ oxidoreductase.

References

    • Askerlund P, Larsson C & Widell S (1988). "Localization of donor and acceptor sites of NADH dehydrogenase activities using inside-out and right-side-out plasma membrane vesicles from plants". FEBS Lett. 239: 23&ndash, 28. doi:10.1016/0014-5793(88)80538-6.
    • Freitas MP (2006). "MIA-QSAR modelling of anti-HIV-1 activities of some 2-amino-6-arylsulfonylbenzonitriles and their thio and sulfinyl congeners". Org. Biomol. Chem. 4 (6): 1154&ndash, 9. doi:10.1039/b516396j. PMID 16525561.
    • Freitas MP (2006). "MIA-QSAR modelling of anti-HIV-1 activities of some 2-amino-6-arylsulfonylbenzonitriles and their thio and sulfinyl congeners". Org. Biomol. Chem. 4 (6): 1154&ndash, 9. doi:10.1039/b516396j. PMID 16525561.
    • Buckhout TJ & Hrubec TC (1986). "Pyridine nucleotide-dependent ferricyanide reduction associated with isolated plasma membranes of maize (Zea mays L.) roots". Protoplasma. 135 (2–3): 144&ndash, 154. doi:10.1007/BF01277007.
    • Sandelius AS, Barr R, Crane FL & Morre DJ (1986). "Redox reactions of plasma membranes isolated from soybean hypocotyls by phase partition". Plant Sci. 48: 1&ndash, 10. doi:10.1016/0168-9452(87)90062-8.


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