Farnesyl-diphosphate farnesyltransferase 1

FDFT1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1EZF, 3ASX, 3LEE, 3Q2Z, 3Q30, 3V66, 3VJ8, 3VJ9, 3VJA, 3VJB, 3VJC, 3WC9, 3WCD, 3WCF, 3WCH, 3WCI, 3WCJ, 3WCL, 3WCM, 3WEF, 3WEG, 3WEH, 3WEI, 3WEJ, 3WEK, 3WSA
Identifiers
Aliases	FDFT1, DGPT, ERG9, SQS, SS, farnesyl-diphosphate farnesyltransferase 1
External IDs	MGI: 102706 HomoloGene: 3281 GeneCards: FDFT1
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8p23.1 Start 11,795,573 bp[1] End 11,839,309 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14 D1|14 33.24 cM Start 63,145,150 bp[2] End 63,179,578 bp[2]
Gene ontology Molecular function • transferase activity • catalytic activity • transferase activity, transferring alkyl or aryl (other than methyl) groups • farnesyl-diphosphate farnesyltransferase activity • squalene synthase activity • protein binding Cellular component • integral component of membrane • membrane • intracellular membrane-bounded organelle • endoplasmic reticulum • endoplasmic reticulum membrane Biological process • steroid metabolic process • sterol biosynthetic process • lipid biosynthetic process • lipid metabolic process • cholesterol metabolic process • biosynthetic process • isoprenoid biosynthetic process • metabolism • steroid biosynthetic process • cholesterol biosynthetic process • ergosterol biosynthetic process • farnesyl diphosphate metabolic process • regulation of lipid metabolic process • regulation of cholesterol biosynthetic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	2222	14137
Ensembl	ENSG00000079459 ENSG00000284967	ENSMUSG00000021273
UniProt	P37268 Q6IAX1	P53798
RefSeq (mRNA)	NM_001287742 NM_001287743 NM_001287744 NM_001287745 NM_001287747 NM_001287748 NM_001287749 NM_001287750 NM_001287751 NM_001287756 NM_004462	NM_010191 NM_001360211
RefSeq (protein)	NP_001274671 NP_001274672 NP_001274673 NP_001274674 NP_001274676 NP_001274677 NP_001274678 NP_001274679 NP_001274680 NP_001274685 NP_004453 NP_001274671.1 NP_001274672.1 NP_004453.3	NP_034321 NP_001347140
Location (UCSC)	Chr 8: 11.8 – 11.84 Mb	Chr 14: 63.15 – 63.18 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Farnesyl-diphosphate farnesyltransferase 1 is a protein that in humans is encoded by the FDFT1 gene. ^[5]

Function

This gene encodes a membrane-associated enzyme located at a branch point in the mevalonate pathway. The encoded protein is the first specific enzyme in cholesterol biosynthesis, catalyzing the dimerization of two molecules of farnesyl diphosphate in a two-step reaction to form squalene.

References

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.