FUNDC1

FUNDC1
Identifiers
AliasesFUNDC1, FUN14 domain containing 1
External IDsMGI: 1919268 HomoloGene: 41738 GeneCards: FUNDC1
Gene location (Human)
Chr.X chromosome (human)[1]
BandXp11.3Start44,523,639 bp[1]
End44,543,001 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

139341

72018

Ensembl

ENSG00000069509

ENSMUSG00000025040

UniProt

Q8IVP5

Q9DB70

RefSeq (mRNA)

NM_173794

NM_028058
NM_001313745
NM_001313746

RefSeq (protein)

NP_776155

NP_001300674
NP_001300675
NP_082334

Location (UCSC)Chr X: 44.52 – 44.54 MbChr X: 17.56 – 17.57 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

FUN14 domain containing 1 is a protein that in humans is encoded by the FUNDC1 gene.[5]

Model organisms

Model organisms have been used in the study of FUNDC1 function. A conditional knockout mouse line, called Fundc1tm1a(KOMP)Wtsi[10][11] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the Wellcome Trust Sanger Institute.[12][13][14]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[8][15] Twenty two tests were carried out on mutant mice, however no significant abnormalities were observed.[8]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000069509 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025040 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ "Entrez Gene: FUN14 domain containing 1". Retrieved 2011-09-19.
  6. ↑ "Salmonella infection data for Fundc1". Wellcome Trust Sanger Institute.
  7. ↑ "Citrobacter infection data for Fundc1". Wellcome Trust Sanger Institute.
  8. 1 2 3 Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica. 88 (S248). doi:10.1111/j.1755-3768.2010.4142.x.
  9. ↑ Mouse Resources Portal, Wellcome Trust Sanger Institute.
  10. ↑ "International Knockout Mouse Consortium".
  11. ↑ "Mouse Genome Informatics".
  12. ↑ Skarnes, W. C.; Rosen, B.; West, A. P.; Koutsourakis, M.; Bushell, W.; Iyer, V.; Mujica, A. O.; Thomas, M.; Harrow, J.; Cox, T.; Jackson, D.; Severin, J.; Biggs, P.; Fu, J.; Nefedov, M.; De Jong, P. J.; Stewart, A. F.; Bradley, A. (2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–342. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.
  13. ↑ Dolgin E (June 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
  14. ↑ Collins FS, Rossant J, Wurst W (January 2007). "A mouse for all reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247.
  15. ↑ van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism". Genome Biol. 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC 3218837. PMID 21722353.

Further reading

Terracciano, A.; Sanna, S.; Uda, M.; Deiana, B.; Usala, G.; Busonero, F.; Maschio, A.; Scally, M.; Patriciu, N.; Chen, W. -M.; Distel, M. A.; Slagboom, E. P.; Boomsma, D. I.; Villafuerte, S.; Sliwerska, E.; Burmeister, M.; Amin, N.; Janssens, A. C. J. W.; Van Duijn, C. M.; Schlessinger, D.; Abecasis, G. R.; Costa Jr, P. T. (2008). "Genome-wide association scan for five major dimensions of personality". Molecular Psychiatry. 15 (6): 647–656. doi:10.1038/mp.2008.113. PMC 2874623. PMID 18957941.


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