FLVCR1

FLVCR1
Identifiers
Aliases	FLVCR1, AXPC1, FLVCR, MFSD7B, PCA, PCARP, feline leukemia virus subgroup C cellular receptor 1
External IDs	MGI: 2444881 HomoloGene: 56661 GeneCards: FLVCR1
Gene location (Human)
Chr.	Chromosome 1 (human)[1]
End	212,899,363 bp[1]
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)[2]
End	191,026,158 bp[2]
RNA expression pattern
	; ;
	More reference expression data
Gene ontology
Molecular function	• transporter activity; • protein binding; • heme transporter activity; • heme binding;
Cellular component	• integral component of membrane; • mitochondrial membrane; • membrane; • plasma membrane; • integral component of plasma membrane; • mitochondrion;
Biological process	• embryonic skeletal system morphogenesis; • head morphogenesis; • limb morphogenesis; • multicellular organism growth; • embryonic digit morphogenesis; • in utero embryonic development; • mitochondrial transport; • spleen development; • heme transport; • multicellular organism development; • blood vessel development; • erythrocyte differentiation; • regulation of organ growth; • heme export; • cellular iron ion homeostasis; • erythrocyte maturation; • transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	28982
	226844
	ENSG00000162769
	ENSMUSG00000066595
	Q9Y5Y0
	B2RXV4
	NM_014053
	NM_001081259; NM_001313747; NM_198025
	NP_054772
	NP_001074728; NP_001300676; NP_932142
	Wikidata
View/Edit Human	View/Edit Mouse

Feline leukemia virus subgroup C receptor-related protein 1 is a protein that in humans is encoded by the FLVCR1 gene (SLC49A1).^[5]^[6]^[7]^[8]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000162769 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000066595 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Tailor CS, Willett BJ, Kabat D (1999). "A putative cell surface receptor for anemia-inducing feline leukemia virus subgroup C is a member of a transporter superfamily". J. Virol. 73 (8): 6500–5. PMC 112732. PMID 10400745.
↑ Quigley JG, Burns CC, Anderson MM, Lynch ED, Sabo KM, Overbaugh J, Abkowitz JL (2000). "Cloning of the cellular receptor for feline leukemia virus subgroup C (FeLV-C), a retrovirus that induces red cell aplasia". Blood. 95 (3): 1093–9. PMID 10648427.
↑ "Entrez Gene: FLVCR feline leukemia virus subgroup C cellular receptor".
↑ Crielaard, Bart J.; Lammers, Twan; Rivella, Stefano (2017-02-03). "Targeting iron metabolism in drug discovery and delivery". Nature Reviews Drug Discovery. advance online publication. doi:10.1038/nrd.2016.248. ISSN 1474-1784.

Lipovich L, Hughes AL, King MC, Abkowitz JL, Quigley JG (2002). "Genomic structure and evolutionary context of the human feline leukemia virus subgroup C receptor (hFLVCR) gene: evidence for block duplications and de novo gene formation within duplicons of the hFLVCR locus". Gene. 286 (2): 203–13. doi:10.1016/S0378-1119(02)00457-2. PMID 11943475.
Quigley JG, Yang Z, Worthington MT, Phillips JD, Sabo KM, Sabath DE, Berg CL, Sassa S, Wood BL, Abkowitz JL (2004). "Identification of a human heme exporter that is essential for erythropoiesis". Cell. 118 (6): 757–66. doi:10.1016/j.cell.2004.08.014. PMID 15369674.
Quigley JG, Gazda H, Yang Z, Ball S, Sieff CA, Abkowitz JL (2006). "Investigation of a putative role for FLVCR, a cytoplasmic heme exporter, in Diamond-Blackfan anemia". Blood Cells Mol. Dis. 35 (2): 189–92. doi:10.1016/j.bcmd.2005.01.005. PMID 15996880.
Brown JK, Fung C, Tailor CS (2006). "Comprehensive mapping of receptor-functioning domains in feline leukemia virus subgroup C receptor FLVCR1". J. Virol. 80 (4): 1742–51. doi:10.1128/JVI.80.4.1742-1751.2006. PMC 1367145. PMID 16439531.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000162769 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000066595 - Ensembl, May 2017

[3] "Human PubMed Reference:".

[4] "Mouse PubMed Reference:".

[pmid10400745-5] Tailor CS, Willett BJ, Kabat D (1999). "A putative cell surface receptor for anemia-inducing feline leukemia virus subgroup C is a member of a transporter superfamily". J. Virol. 73 (8): 6500–5. PMC 112732. PMID 10400745.

[pmid10648427-6] Quigley JG, Burns CC, Anderson MM, Lynch ED, Sabo KM, Overbaugh J, Abkowitz JL (2000). "Cloning of the cellular receptor for feline leukemia virus subgroup C (FeLV-C), a retrovirus that induces red cell aplasia". Blood. 95 (3): 1093–9. PMID 10648427.

[entrez-7] "Entrez Gene: FLVCR feline leukemia virus subgroup C cellular receptor".

[8] Crielaard, Bart J.; Lammers, Twan; Rivella, Stefano (2017-02-03). "Targeting iron metabolism in drug discovery and delivery". Nature Reviews Drug Discovery. advance online publication. doi:10.1038/nrd.2016.248. ISSN 1474-1784.

FLVCR1

References

Further reading