FIBP

FIBP
Identifiers
AliasesFIBP, FGFIBP-1, FGF1 intracellular binding protein, TROFAS
External IDsMGI: 1926233 HomoloGene: 3106 GeneCards: FIBP
Gene location (Human)
Chr.Chromosome 11 (human)[1]
Band11q13.1Start65,883,741 bp[1]
End65,888,539 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

9158

58249

Ensembl

ENSG00000172500

ENSMUSG00000024911

UniProt

O43427

Q9JI19

RefSeq (mRNA)

NM_004214
NM_198897

NM_001253832
NM_021438

RefSeq (protein)

NP_004205
NP_942600

NP_001240761
NP_067413

Location (UCSC)Chr 11: 65.88 – 65.89 MbChr 19: 5.46 – 5.47 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Acidic fibroblast growth factor intracellular-binding protein is a protein that in humans is encoded by the FIBP gene.[5][6]

Function

Acidic fibroblast growth factor is mitogenic for a variety of different cell types and acts by stimulating mitogenesis or inducing morphological changes and differentiation. The FIBP protein is an intracellular protein that binds selectively to acidic fibroblast growth factor (aFGF). It is postulated that FIBP may be involved in the mitogenic action of aFGF. Two transcript variants encoding different isoforms have been found for this gene.[6]

Interactions

FIBP has been shown to interact with FGF1.[5]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000172500 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024911 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. 1 2 Kolpakova, E; Wiedłocha, A; Stenmark, H; Klingenberg, O; Faines, PO; Olsnes, S (15 November 1998). "Cloning of an intracellular protein that binds selectively to mitogenic acidic fibroblast growth factor". Biochem. J. 336 (1): 213–22. doi:10.1042/bj3360213. PMC 1219860. PMID 9806903.
  6. 1 2 "Entrez Gene: FIBP fibroblast growth factor (acidic) intracellular binding protein".

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Kolpakova E, Frengen E, Stokke T, Olsnes S (2000). "Organization, chromosomal localization and promoter analysis of the gene encoding human acidic fibroblast growth factor intracellular binding protein". Biochem. J. 352 (3): 629–35. doi:10.1042/0264-6021:3520629. PMC 1221498. PMID 11104667.
  • Tassi E, Al-Attar A, Aigner A, Swift MR, McDonnell K, Karavanov A, Wellstein A (2001). "Enhancement of fibroblast growth factor (FGF) activity by an FGF-binding protein". J. Biol. Chem. 276 (43): 40247–53. doi:10.1074/jbc.M104933200. PMID 11509569.
  • Skjerpen CS, Nilsen T, Wesche J, Olsnes S (2002). "Binding of FGF-1 variants to protein kinase CK2 correlates with mitogenicity". EMBO J. 21 (15): 4058–69. doi:10.1093/emboj/cdf402. PMC 126148. PMID 12145206.
  • Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.


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