FGFR1OP

FGFR1OP
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesFGFR1OP, FOP, FGFR1 oncogene partner
External IDsMGI: 1922546 HomoloGene: 5116 GeneCards: FGFR1OP
Gene location (Human)
Chr.Chromosome 6 (human)[1]
Band6q27Start166,999,182 bp[1]
End167,094,789 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

11116

75296

Ensembl

ENSG00000213066

ENSMUSG00000069135

UniProt

O95684

Q66JX5

RefSeq (mRNA)

NM_194429
NM_001278690
NM_007045

NM_001197046
NM_201230

RefSeq (protein)

NP_001265619
NP_008976
NP_919410

NP_001183975
NP_957682

Location (UCSC)Chr 6: 167 – 167.09 MbChr 17: 8.17 – 8.2 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

FGFR1 oncogene partner is a protein that in humans is encoded by the FGFR1OP gene.[5][6][7]

Function

This gene encodes a largely hydrophilic protein postulated to be a leucine-rich protein family member. A t(6;8)(q27;p11) chromosomal translocation, fusing this gene and the fibroblast growth factor receptor 1 (FGFR1) gene, has been found in cases of myeloproliferative disorder. The resulting chimeric protein contains the N-terminal leucine-rich region of this encoded protein fused to the catalytic domain of FGFR1. This gene is thought to play an important role in normal proliferation and differentiation of the erythroid lineage. Alternatively spliced transcript variants that encode different proteins have been identified.[7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000213066 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000069135 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Popovici C, Zhang B, Grégoire MJ, Jonveaux P, Lafage-Pochitaloff M, Birnbaum D, Pébusque MJ (February 1999). "The t(6;8)(q27;p11) translocation in a stem cell myeloproliferative disorder fuses a novel gene, FOP, to fibroblast growth factor receptor 1". Blood. 93 (4): 1381–9. PMID 9949182.
  6. ↑ Reither A, Hehlmann R, Goldman JM, Cross NC (April 1999). "[The 8p11 myeloproliferative syndrome]". Medizinische Klinik. 94 (4): 207–10. PMID 10373756.
  7. 1 2 "Entrez Gene: FGFR1OP FGFR1 oncogene partner".

Further reading

  • Guasch G, Ollendorff V, Borg JP, Birnbaum D, Pébusque MJ (December 2001). "8p12 stem cell myeloproliferative disorder: the FOP-fibroblast growth factor receptor 1 fusion protein of the t(6;8) translocation induces cell survival mediated by mitogen-activated protein kinase and phosphatidylinositol 3-kinase/Akt/mTOR pathways". Molecular and Cellular Biology. 21 (23): 8129–42. doi:10.1128/MCB.21.23.8129-8142.2001. PMC 99978. PMID 11689702.
  • Guasch G, Delaval B, Arnoulet C, Xie MJ, Xerri L, Sainty D, Birnbaum D, Pébusque MJ (January 2004). "FOP-FGFR1 tyrosine kinase, the product of a t(6;8) translocation, induces a fatal myeloproliferative disease in mice". Blood. 103 (1): 309–12. doi:10.1182/blood-2003-05-1690. PMID 12969958.
  • Andersen JS, Wilkinson CJ, Mayor T, Mortensen P, Nigg EA, Mann M (December 2003). "Proteomic characterization of the human centrosome by protein correlation profiling". Nature. 426 (6966): 570–4. doi:10.1038/nature02166. PMID 14654843.
  • Brill LM, Salomon AR, Ficarro SB, Mukherji M, Stettler-Gill M, Peters EC (May 2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Analytical Chemistry. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.
  • Yan X, Habedanck R, Nigg EA (February 2006). "A complex of two centrosomal proteins, CAP350 and FOP, cooperates with EB1 in microtubule anchoring". Molecular Biology of the Cell. 17 (2): 634–44. doi:10.1091/mbc.E05-08-0810. PMC 1356575. PMID 16314388.
  • Mikolajka A, Yan X, Popowicz GM, Smialowski P, Nigg EA, Holak TA (June 2006). "Structure of the N-terminal domain of the FOP (FGFR1OP) protein and implications for its dimerization and centrosomal localization". Journal of Molecular Biology. 359 (4): 863–75. doi:10.1016/j.jmb.2006.03.070. PMID 16690081.
  • Mano Y, Takahashi K, Ishikawa N, Takano A, Yasui W, Inai K, Nishimura H, Tsuchiya E, Nakamura Y, Daigo Y (December 2007). "Fibroblast growth factor receptor 1 oncogene partner as a novel prognostic biomarker and therapeutic target for lung cancer". Cancer Science. 98 (12): 1902–13. doi:10.1111/j.1349-7006.2007.00610.x. PMID 17888034.


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