FCRLA

FCRLA
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesFCRLA, FCRL, FCRL1, FCRLM1, FCRLX, FCRLb, FCRLc1, FCRLc2, FCRLd, FCRLe, FCRX, FREB, Fc receptor like A
External IDsMGI: 2138647 HomoloGene: 13106 GeneCards: FCRLA
Gene location (Human)
Chr.Chromosome 1 (human)[1]
Band1q23.3Start161,706,972 bp[1]
End161,714,352 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

84824

98752

Ensembl

ENSG00000132185

ENSMUSG00000038421

UniProt

Q7L513

Q920A9

RefSeq (mRNA)

NM_001160215
NM_145141

RefSeq (protein)

NP_001153687
NP_660123

Location (UCSC)Chr 1: 161.71 – 161.71 MbChr 1: 170.92 – 170.93 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Fc receptor-like A is a protein that in humans is encoded by the FCRLA gene.[5][6]

Receptors for the Fc fragment of IgG, or FCGRs (see MIM 146790), are cell surface glycoproteins of the Ig superfamily (IgSF). These receptors mediate phagocytosis of IgG-coated pathogens and promote activation of effector cells, leading to inflammatory responses and antibody-mediated cellular cytotoxicity. All FCGR genes map to human chromosome 1. Additional genes in this region, including FREB, encode FCGR homologs that are selectively expressed in B cells and may be implicated in B-cell development and lymphomagenesis.[supplied by OMIM][6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000132185 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000038421 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Mechetina LV, Najakshin AM, Volkova OY, Guselnikov SV, Faizulin RZ, Alabyev BY, Chikaev NA, Vinogradova MS, Taranin AV (Dec 2001). "FCRL, a novel member of the leukocyte Fc receptor family possesses unique structural features". Eur J Immunol. 32 (1): 87–96. doi:10.1002/1521-4141(200201)32:1<87::AID-IMMU87>3.0.CO;2-#. PMID 11754007.
  6. 1 2 "Entrez Gene: FCRLA Fc receptor-like A".

Further reading

  • Facchetti F, Cella M, Festa S, et al. (2002). "An unusual Fc receptor-related protein expressed in human centroblasts". Proc. Natl. Acad. Sci. U.S.A. 99 (6): 3776–81. doi:10.1073/pnas.022042699. PMC 122600. PMID 11891275.
  • Davis RS, Li H, Chen CC, et al. (2003). "Definition of an Fc receptor-related gene (FcRX) expressed in human and mouse B cells". Int. Immunol. 14 (9): 1075–83. doi:10.1093/intimm/dxf074. PMID 12202404.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Huizinga TW, Ioan-Facsinay A (2004). "Soluble FcgammaRIIIa as a marker for rheumatoid arthritis: the use of genetics in selected populations to study pathogenetic pathways". J. Rheumatol. 30 (9): 1904–6. PMID 12966588.
  • Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
  • Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Inozume T, Matsuzaki Y, Kurihara S, et al. (2005). "Novel melanoma antigen, FCRL/FREB, identified by cDNA profile comparison using DNA chip are immunogenic in multiple melanoma patients". Int. J. Cancer. 114 (2): 283–90. doi:10.1002/ijc.20735. PMID 15551350.
  • Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
  • Taylor AI, Gould HJ, Sutton BJ, Calvert RA (2007). "The first avian Ig-like Fc receptor family member combines features of mammalian FcR and FCRL". Immunogenetics. 59 (4): 323–8. doi:10.1007/s00251-007-0195-9. PMID 17273841.


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