FCGRT

FCGRT
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1EXU, 3M17, 3M1B, 4K71, 4N0F, 4N0U, 5BXF
Identifiers
Aliases	FCGRT, FCRN, alpha-chain, Fc fragment of IgG receptor and transporter
External IDs	MGI: 103017 HomoloGene: 3030 GeneCards: FCGRT
Gene location (Human)
Chr.	Chromosome 19 (human)[1]
End	49,526,333 bp[1]
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)[2]
End	45,103,851 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• peptide antigen binding; • IgG receptor activity; • beta-2-microglobulin binding; • IgG binding;
Cellular component	• integral component of membrane; • plasma membrane; • membrane;
Biological process	• IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor; • Fc-gamma receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	2217
	14132
	ENSG00000104870
	ENSMUSG00000003420
	P55899
	Q61559
	NM_001136019; NM_004107
	NM_010189; NM_001357117
	NP_001129491; NP_004098
	NP_034319; NP_001344046
	Wikidata
View/Edit Human	View/Edit Mouse

IgG receptor FcRn large subunit p51 is a protein that in humans is encoded by the FCGRT gene.^[5]^[6]^[7]

Interactions

FCGRT has been shown to interact with Human serum albumin.^[8]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000104870 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000003420 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Story CM, Mikulska JE, Simister NE (December 1994). "A major histocompatibility complex class I-like Fc receptor cloned from human placenta: possible role in transfer of immunoglobulin G from mother to fetus". J. Exp. Med. 180 (6): 2377–81. doi:10.1084/jem.180.6.2377. PMC 2191771. PMID 7964511.
↑ Kandil E, Egashira M, Miyoshi O, Niikawa N, Ishibashi T, Kasahara M, Miyosi O (July 1996). "The human gene encoding the heavy chain of the major histocompatibility complex class I-like Fc receptor (FCGRT) maps to 19q13.3". Cytogenet. Cell Genet. 73 (1–2): 97–8. doi:10.1159/000134316. PMID 8646894.
↑ "Entrez Gene: FCGRT Fc fragment of IgG, receptor, transporter, alpha".
↑ Chaudhury C, Mehnaz S, Robinson JM, Hayton WL, Pearl DK, Roopenian DC, Anderson CL (February 2003). "The major histocompatibility complex-related Fc receptor for IgG (FcRn) binds albumin and prolongs its lifespan". J. Exp. Med. 197 (3): 315–22. doi:10.1084/jem.20021829. PMC 2193842. PMID 12566415.

Dürrbaum-Landmann I, Kaltenhäuser E, Flad HD, Ernst M (1994). "HIV-1 envelope protein gp120 affects phenotype and function of monocytes in vitro". J. Leukoc. Biol. 55 (4): 545–51. PMID 8145026.
Leach JL, Sedmak DD, Osborne JM, Rahill B, Lairmore MD, Anderson CL (1996). "Isolation from human placenta of the IgG transporter, FcRn, and localization to the syncytiotrophoblast: implications for maternal-fetal antibody transport". J. Immunol. 157 (8): 3317–22. PMID 8871627.
Kivelä J, Parkkila S, Waheed A, Parkkila AK, Sly WS, Rajaniemi H (1997). "Secretory carbonic anhydrase isoenzyme (CA VI) in human serum". Clin. Chem. 43 (12): 2318–22. PMID 9439449.
Vaughn DE, Bjorkman PJ (1998). "Structural basis of pH-dependent antibody binding by the neonatal Fc receptor". Structure. 6 (1): 63–73. doi:10.1016/S0969-2126(98)00008-2. PMID 9493268.
West AP, Bjorkman PJ (2000). "Crystal structure and immunoglobulin G binding properties of the human major histocompatibility complex-related Fc receptor(,)". Biochemistry. 39 (32): 9698–708. doi:10.1021/bi000749m. PMID 10933786.
Mikulska JE, Pablo L, Canel J, Simister NE (2000). "Cloning and analysis of the gene encoding the human neonatal Fc receptor". Eur. J. Immunogenet. 27 (4): 231–40. doi:10.1046/j.1365-2370.2000.00225.x. PMID 10998088.
Zhu X, Meng G, Dickinson BL, Li X, Mizoguchi E, Miao L, Wang Y, Robert C, Wu B, Smith PD, Lencer WI, Blumberg RS (2001). "MHC class I-related neonatal Fc receptor for IgG is functionally expressed in monocytes, intestinal macrophages, and dendritic cells". J. Immunol. 166 (5): 3266–76. doi:10.4049/jimmunol.166.5.3266. PMC 2827247. PMID 11207281.
Ober RJ, Radu CG, Ghetie V, Ward ES (2001). "Differences in promiscuity for antibody-FcRn interactions across species: implications for therapeutic antibodies". Int. Immunol. 13 (12): 1551–9. doi:10.1093/intimm/13.12.1551. PMID 11717196.
Praetor A, Hunziker W (2002). "beta(2)-Microglobulin is important for cell surface expression and pH-dependent IgG binding of human FcRn". J. Cell Sci. 115 (Pt 11): 2389–97. PMID 12006623.
Claypool SM, Dickinson BL, Yoshida M, Lencer WI, Blumberg RS (2002). "Functional reconstitution of human FcRn in Madin-Darby canine kidney cells requires co-expressed human beta 2-microglobulin". J. Biol. Chem. 277 (31): 28038–50. doi:10.1074/jbc.M202367200. PMC 2825174. PMID 12023961.
Praetor A, Jones RM, Wong WL, Hunziker W (2002). "Membrane-anchored human FcRn can oligomerize in the absence of IgG". J. Mol. Biol. 321 (2): 277–84. doi:10.1016/S0022-2836(02)00626-5. PMID 12144784.
Shah U, Dickinson BL, Blumberg RS, Simister NE, Lencer WI, Walker WA (2003). "Distribution of the IgG Fc receptor, FcRn, in the human fetal intestine". Pediatr. Res. 53 (2): 295–301. doi:10.1203/01.pdr.0000047663.81816.e3. PMC 2819091. PMID 12538789.
Chaudhury C, Mehnaz S, Robinson JM, Hayton WL, Pearl DK, Roopenian DC, Anderson CL (2003). "The major histocompatibility complex-related Fc receptor for IgG (FcRn) binds albumin and prolongs its lifespan". J. Exp. Med. 197 (3): 315–22. doi:10.1084/jem.20021829. PMC 2193842. PMID 12566415.
Schilling R, Ijaz S, Davidoff M, Lee JY, Locarnini S, Williams R, Naoumov NV (2003). "Endocytosis of hepatitis B immune globulin into hepatocytes inhibits the secretion of hepatitis B virus surface antigen and virions". J. Virol. 77 (16): 8882–92. doi:10.1128/JVI.77.16.8882-8892.2003. PMC 167249. PMID 12885906.
Zhou J, Johnson JE, Ghetie V, Ober RJ, Ward ES (2003). "Generation of mutated variants of the human form of the MHC class I-related receptor, FcRn, with increased affinity for mouse immunoglobulin G". J. Mol. Biol. 332 (4): 901–13. doi:10.1016/S0022-2836(03)00952-5. PMID 12972260.
Cianga P, Cianga C, Cozma L, Ward ES, Carasevici E (2003). "The MHC class I related Fc receptor, FcRn, is expressed in the epithelial cells of the human mammary gland". Hum. Immunol. 64 (12): 1152–9. doi:10.1016/j.humimm.2003.08.025. PMID 14630397.
Ober RJ, Martinez C, Vaccaro C, Zhou J, Ward ES (2004). "Visualizing the site and dynamics of IgG salvage by the MHC class I-related receptor, FcRn". J. Immunol. 172 (4): 2021–9. doi:10.4049/jimmunol.172.4.2021. PMID 14764666.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000104870 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000003420 - Ensembl, May 2017

[3] "Human PubMed Reference:".

[4] "Mouse PubMed Reference:".

[pmid7964511-5] Story CM, Mikulska JE, Simister NE (December 1994). "A major histocompatibility complex class I-like Fc receptor cloned from human placenta: possible role in transfer of immunoglobulin G from mother to fetus". J. Exp. Med. 180 (6): 2377–81. doi:10.1084/jem.180.6.2377. PMC 2191771. PMID 7964511.

[pmid8646894-6] Kandil E, Egashira M, Miyoshi O, Niikawa N, Ishibashi T, Kasahara M, Miyosi O (July 1996). "The human gene encoding the heavy chain of the major histocompatibility complex class I-like Fc receptor (FCGRT) maps to 19q13.3". Cytogenet. Cell Genet. 73 (1–2): 97–8. doi:10.1159/000134316. PMID 8646894.

[7] "Entrez Gene: FCGRT Fc fragment of IgG, receptor, transporter, alpha".

[pmid12566415-8] Chaudhury C, Mehnaz S, Robinson JM, Hayton WL, Pearl DK, Roopenian DC, Anderson CL (February 2003). "The major histocompatibility complex-related Fc receptor for IgG (FcRn) binds albumin and prolongs its lifespan". J. Exp. Med. 197 (3): 315–22. doi:10.1084/jem.20021829. PMC 2193842. PMID 12566415.

FCGRT

Interactions

References

Further reading