Endozepine
Endozepines are endogenous compounds with benzodiazepine like effects. They have been linked to hepatic encephalopathy and have controversially been linked to some cases of recurrent stupor.[1] Initially, the key diagnostic test is stupor which is sensitive to the benzodiazepine receptor antagonist flumazenil in the absences of exogenous benzodiazepines.
Potential candidates for these compounds are:[2]
- oleamides
- nonpeptidic endozepines
- the protein Diazepam binding inhibitor (DBI)
References
- ↑ Cortelli, P.; Avallone, R.; Baraldi, M.; Zeneroli, ML.; Mandrioli, J.; Corsi, L.; Riva, R.; Tinuper, P.; et al. (Dec 2005). "Endozepines in recurrent stupor". Sleep Med Rev. 9 (6): 477–87. doi:10.1016/j.smrv.2005.07.003. PMID 16233983.
- ↑ Farzampour, Z; Reimer, RJ; Huguenard, J (2015). "Endozepines". Advances in pharmacology (San Diego, Calif.). 72: 147–64. doi:10.1016/bs.apha.2014.10.005. PMC 4550098. PMID 25600369.
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