Ectoine synthase

Ectoine synthase
Identifiers
EC number 4.2.1.108
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

In enzymology, an ectoine synthase (EC 4.2.1.108) is an enzyme that catalyzes the chemical reaction

N4-acetyl-L-2,4-diaminobutanoate L-ectoine + H2O

Hence, this enzyme has one substrate, N4-acetyl-L-2,4-diaminobutanoate, and two products, L-ectoine and H2O.

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is N4-acetyl-L-2,4-diaminobutanoate hydro-lyase (L-ectoine-forming). Other names in common use include N-acetyldiaminobutyrate dehydratase, N-acetyldiaminobutanoate dehydratase, L-ectoine synthase, EctC, and 4-N-acetyl-L-2,4-diaminobutanoate hydro-lyase (L-ectoine-forming). This enzyme participates in glycine, serine and threonine metabolism.

References

    • Peters P, Galinski EA & Truper HG (1990). "The biosynthesis of ectoine". FEMS Microbiol. Lett. 71: 157&ndash, 162. doi:10.1111/j.1574-6968.1990.tb03815.x.
    • Ono H, Sawada K, Khunajakr N, et al. (1999). "Characterization of biosynthetic enzymes for ectoine as a compatible solute in a moderately halophilic eubacterium, Halomonas elongata". J. Bacteriol. 181 (1): 91&ndash, 9. PMC 103536. PMID 9864317.
    • Kuhlmann AU, Bremer E (2002). "Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp". Appl. Environ. Microbiol. 68 (2): 772&ndash, 83. doi:10.1128/AEM.68.2.772-783.2002. PMC 126723. PMID 11823218.
    • Louis P, Galinski EA. "Characterization of genes for the biosynthesis of the compatible solute ectoine from Marinococcus halophilus and osmoregulated expression in Escherichia coli". Microbiology. 143 (4): 1141&ndash, 9. doi:10.1099/00221287-143-4-1141. PMID 9141677.


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