ERLIN2

ERLIN2
Identifiers
AliasesERLIN2, C8orf2, Erlin-2, NET32, SPFH2, SPG18, ER lipid raft associated 2
External IDsMGI: 2387215 HomoloGene: 5193 GeneCards: ERLIN2
Gene location (Human)
Chr.Chromosome 8 (human)[1]
Band8p11.23Start37,736,599 bp[1]
End37,759,101 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

11160

244373

Ensembl

ENSG00000147475

ENSMUSG00000031483

UniProt

O94905

Q8BFZ9

RefSeq (mRNA)

NM_001003790
NM_001003791
NM_007175
NM_001362878
NM_001362880

NM_153592
NM_001364476
NM_001364477

RefSeq (protein)

NP_001003790
NP_001003791
NP_009106
NP_001349807
NP_001349809

NP_705820
NP_001351405
NP_001351406

Location (UCSC)Chr 8: 37.74 – 37.76 MbChr 8: 27.02 – 27.04 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Erlin-2 is a protein that in humans is encoded by the ERLIN2 gene.[5][6][7][8]

Model organisms

Model organisms have been used in the study of ERLIN2 function. A conditional knockout mouse line called Erlin2tm1a(EUCOMM)Wtsi was generated at the Wellcome Trust Sanger Institute.[9] Male and female animals underwent a standardized phenotypic screen[10] to determine the effects of deletion.[11][12][13][14] Additional screens performed: - In-depth immunological phenotyping[15]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000147475 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031483 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Ikegawa S, Isomura M, Koshizuka Y, Nakamura Y (Oct 1999). "Cloning and characterization of a novel gene (C8orf2), a human representative of a novel gene family with homology to C. elegans C42.C1.9". Cytogenetics and Cell Genetics. 85 (3–4): 227–31. doi:10.1159/000015298. PMID 10449903.
  6. ↑ Garcia MJ, Pole JC, Chin SF, Teschendorff A, Naderi A, Ozdag H, Vias M, Kranjac T, Subkhankulova T, Paish C, Ellis I, Brenton JD, Edwards PA, Caldas C (Aug 2005). "A 1 Mb minimal amplicon at 8p11-12 in breast cancer identifies new candidate oncogenes". Oncogene. 24 (33): 5235–45. doi:10.1038/sj.onc.1208741. PMID 15897872.
  7. ↑ Browman DT, Resek ME, Zajchowski LD, Robbins SM (Aug 2006). "Erlin-1 and erlin-2 are novel members of the prohibitin family of proteins that define lipid-raft-like domains of the ER". Journal of Cell Science. 119 (Pt 15): 3149–60. doi:10.1242/jcs.03060. PMID 16835267.
  8. ↑ "Entrez Gene: ERLIN2 ER lipid raft associated 2".
  9. ↑ Gerdin AK (2010). "The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice". Acta Ophthalmologica. 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x.
  10. 1 2 "International Mouse Phenotyping Consortium".
  11. ↑ Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A (Jun 2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–42. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.
  12. ↑ Dolgin E (Jun 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
  13. ↑ Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247.
  14. ↑ White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN, Salisbury J, Clare S, Ingham NJ, Podrini C, Houghton R, Estabel J, Bottomley JR, Melvin DG, Sunter D, Adams NC, Tannahill D, Logan DW, Macarthur DG, Flint J, Mahajan VB, Tsang SH, Smyth I, Watt FM, Skarnes WC, Dougan G, Adams DJ, Ramirez-Solis R, Bradley A, Steel KP (Jul 2013). "Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes". Cell. 154 (2): 452–64. doi:10.1016/j.cell.2013.06.022. PMC 3717207. PMID 23870131.
  15. 1 2 "Infection and Immunity Immunophenotyping (3i) Consortium".

Further reading

  • Bonaldo MF, Lennon G, Soares MB (Sep 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
  • Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (Sep 2000). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Reports. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
  • Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S (Sep 2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Research. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
  • Pearce MM, Wang Y, Kelley GG, Wojcikiewicz RJ (Jul 2007). "SPFH2 mediates the endoplasmic reticulum-associated degradation of inositol 1,4,5-trisphosphate receptors and other substrates in mammalian cells". The Journal of Biological Chemistry. 282 (28): 20104–15. doi:10.1074/jbc.M701862200. PMID 17502376.


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