ELL3

ELL3
Identifiers
Aliases	ELL3, ELL3 (gene), elongation factor for RNA polymerase II 3
External IDs	MGI: 2673679 HomoloGene: 11859 GeneCards: ELL3
Gene location (Human)
Chr.	Chromosome 15 (human)[1]
End	43,777,543 bp[1]
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)[2]
End	121,444,278 bp[2]
Gene ontology
Molecular function	• enhancer binding; • protein binding;
Cellular component	• nucleolus; • transcription elongation factor complex; • cell nucleus; • nucleoplasm;
Biological process	• positive regulation of DNA-templated transcription, elongation; • positive regulation of neurogenesis; • positive regulation of neural precursor cell proliferation; • transcription elongation from RNA polymerase II promoter; • regulation of epithelial to mesenchymal transition; • DNA-templated transcription, elongation; • regulation of transcription, DNA-templated; • negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; • transcription from RNA polymerase II promoter; • spermatogenesis; • positive regulation of transcription from RNA polymerase II promoter; • stem cell differentiation; • transcription, DNA-templated; • negative regulation of signal transduction by p53 class mediator; • snRNA transcription from RNA polymerase II promoter;
	Sources:Amigo / QuickGO
Orthologs
	80237
	269344
	ENSG00000128886
	ENSMUSG00000027246
	Q9HB65
	Q80VR2
	NM_025165
	NM_145973
	NP_079441
	NP_666085
	Wikidata
View/Edit Human	View/Edit Mouse

Elongation factor RNA polymerase II-like 3 is a protein that in humans is encoded by the ELL3 gene.^[5]

References

Takahashi H, Parmely TJ, Sato S, Tomomori-Sato C, Banks CA, Kong SE, Szutorisz H, Swanson SK, Martin-Brown S, Washburn MP, Florens L, Seidel CW, Lin C, Smith ER, Shilatifard A, Conaway RC, Conaway JW (July 2011). "Human mediator subunit MED26 functions as a docking site for transcription elongation factors". Cell. 146 (1): 92–104. doi:10.1016/j.cell.2011.06.005. PMC 3145325. PMID 21729782.
Park G, Gong Z, Chen J, Kim JE (April 2010). "Characterization of the DOT1L network: implications of diverse roles for DOT1L". The Protein Journal. 29 (3): 213–23. doi:10.1007/s10930-010-9242-8. PMID 20431927.
Miller T, Williams K, Johnstone RW, Shilatifard A (October 2000). "Identification, cloning, expression, and biochemical characterization of the testis-specific RNA polymerase II elongation factor ELL3". The Journal of Biological Chemistry. 275 (41): 32052–6. doi:10.1074/jbc.M005175200. PMID 10882741.
Law IK, Liu L, Xu A, Lam KS, Vanhoutte PM, Che CM, Leung PT, Wang Y (May 2009). "Identification and characterization of proteins interacting with SIRT1 and SIRT3: implications in the anti-aging and metabolic effects of sirtuins". Proteomics. 9 (9): 2444–56. doi:10.1002/pmic.200800738. PMID 19343720.

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