EDIL3

EDIL3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesEDIL3, DEL1, EGF like repeats and discoidin domains 3
External IDsMGI: 1329025 HomoloGene: 21166 GeneCards: EDIL3
Gene location (Human)
Chr.Chromosome 5 (human)[1]
Band5q14.3Start83,940,554 bp[1]
End84,384,793 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

10085

13612

Ensembl

ENSG00000164176

ENSMUSG00000034488

UniProt

O43854

O35474

RefSeq (mRNA)

NM_001278642
NM_005711

NM_001037987
NM_010103

RefSeq (protein)

NP_001265571
NP_005702

NP_001033076
NP_034233

Location (UCSC)Chr 5: 83.94 – 84.38 MbChr 13: 88.82 – 89.32 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

EGF like repeats and discoidin domains 3 is a protein that in humans is encoded by the EDIL3 gene. [5]

Function

The protein encoded by this gene is an integrin ligand. It plays an important role in mediating angiogenesis and may be important in vessel wall remodeling and development. It also influences endothelial cell behavior.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000164176 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000034488 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ "Entrez Gene: EGF like repeats and discoidin domains 3". Retrieved 2017-07-24.

Further reading

  • Rezaee M, Penta K, Quertermous T (2002). "Del1 mediates VSMC adhesion, migration, and proliferation through interaction with integrin alpha(v)beta(3)". Am. J. Physiol. Heart Circ. Physiol. 282 (5): H1924–32. doi:10.1152/ajpheart.00921.2001. PMID 11959660.
  • Aoka Y, Johnson FL, Penta K, Hirata Ki K, Hidai C, Schatzman R, Varner JA, Quertermous T (2002). "The embryonic angiogenic factor Del1 accelerates tumor growth by enhancing vascular formation". Microvasc. Res. 64 (1): 148–61. doi:10.1006/mvre.2002.2414. PMID 12074641.
  • Niu JX, Zhang WJ, Ye LY, Wu LQ, Zhu GJ, Yang ZH, Grau GE, Lou JN (2007). "The role of adhesion molecules, alpha v beta 3, alpha v beta 5 and their ligands in the tumor cell and endothelial cell adhesion". Eur. J. Cancer Prev. 16 (6): 517–27. doi:10.1097/CEJ.0b013e3280145c00. PMID 18090124.
  • Zou X, Qiao H, Jiang X, Dong X, Jiang H, Sun X (2009). "Downregulation of developmentally regulated endothelial cell locus-1 inhibits the growth of colon cancer". J. Biomed. Sci. 16: 33. doi:10.1186/1423-0127-16-33. PMC 2666667. PMID 19292890.
  • Johnson MP, Roten LT, Dyer TD, East CE, Forsmo S, Blangero J, Brennecke SP, Austgulen R, Moses EK (2009). "The ERAP2 gene is associated with preeclampsia in Australian and Norwegian populations". Hum. Genet. 126 (5): 655–66. doi:10.1007/s00439-009-0714-x. PMC 2783187. PMID 19578876.
  • Bozaoglu K, Curran JE, Stocker CJ, Zaibi MS, Segal D, Konstantopoulos N, Morrison S, Carless M, Dyer TD, Cole SA, Goring HH, Moses EK, Walder K, Cawthorne MA, Blangero J, Jowett JB (2010). "Chemerin, a novel adipokine in the regulation of angiogenesis". J. Clin. Endocrinol. Metab. 95 (5): 2476–85. doi:10.1210/jc.2010-0042. PMC 2869547. PMID 20237162.
  • Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
  • Sun JC, Liang XT, Pan K, Wang H, Zhao JJ, Li JJ, Ma HQ, Chen YB, Xia JC (2010). "High expression level of EDIL3 in HCC predicts poor prognosis of HCC patients". World J. Gastroenterol. 16 (36): 4611–5. PMC 2945496. PMID 20857535.
  • Glessner JT, Bradfield JP, Wang K, Takahashi N, Zhang H, Sleiman PM, Mentch FD, Kim CE, Hou C, Thomas KA, Garris ML, Deliard S, Frackelton EC, Otieno FG, Zhao J, Chiavacci RM, Li M, Buxbaum JD, Berkowitz RI, Hakonarson H, Grant SF (2010). "A genome-wide study reveals copy number variants exclusive to childhood obesity cases". Am. J. Hum. Genet. 87 (5): 661–6. doi:10.1016/j.ajhg.2010.09.014. PMC 2978976. PMID 20950786.


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