EDEM3

EDEM3
Identifiers
AliasesEDEM3, C1orf22, ER degradation enhancing alpha-mannosidase like protein 3
External IDsMGI: 1914217 HomoloGene: 11866 GeneCards: EDEM3
Gene location (Human)
Chr.Chromosome 1 (human)[1]
Band1q25.3Start184,690,231 bp[1]
End184,754,913 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

80267

66967

Ensembl

ENSG00000116406

ENSMUSG00000043019

UniProt

Q9BZQ6

Q2HXL6

RefSeq (mRNA)

NM_025191
NM_001319960

NM_001039644
NM_001311165
NM_001311166

RefSeq (protein)

NP_001306889
NP_079467

NP_001034733
NP_001298094
NP_001298095

Location (UCSC)Chr 1: 184.69 – 184.75 MbChr 1: 151.76 – 151.82 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

ER degradation-enhancing alpha-mannosidase-like 3 is an enzyme that in humans is encoded by the EDEM3 gene.[5][6][7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000116406 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000043019 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Mast SW, Diekman K, Karaveg K, Davis A, Sifers RN, Moremen KW (Mar 2005). "Human EDEM2, a novel homolog of family 47 glycosidases, is involved in ER-associated degradation of glycoproteins". Glycobiology. 15 (4): 421–36. doi:10.1093/glycob/cwi014. PMID 15537790.
  6. ↑ Olivari S, Galli C, Alanen H, Ruddock L, Molinari M (Jan 2005). "A novel stress-induced EDEM variant regulating endoplasmic reticulum-associated glycoprotein degradation". J Biol Chem. 280 (4): 2424–8. doi:10.1074/jbc.C400534200. PMID 15579471.
  7. ↑ "Entrez Gene: EDEM3 ER degradation enhancer, mannosidase alpha-like 3".

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Sood R, Bonner TI, Makalowska I, et al. (2001). "Cloning and characterization of 13 novel transcripts and the human RGS8 gene from the 1q25 region encompassing the hereditary prostate cancer (HPC1) locus". Genomics. 73 (2): 211–22. doi:10.1006/geno.2001.6500. PMID 11318611.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • Hirao K, Natsuka Y, Tamura T, et al. (2006). "EDEM3, a soluble EDEM homolog, enhances glycoprotein endoplasmic reticulum-associated degradation and mannose trimming". J. Biol. Chem. 281 (14): 9650–8. doi:10.1074/jbc.M512191200. PMID 16431915.
  • Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.


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