Cyclohexa-1,5-dienecarbonyl-CoA hydratase

cyclohexa-1,5-dienecarbonyl-CoA hydratase
Identifiers
EC number 4.2.1.100
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO

In enzymology, a cyclohexa-1,5-dienecarbonyl-CoA hydratase (EC 4.2.1.100) is an enzyme that catalyzes the chemical reaction

6-hydroxycyclohex-1-enecarbonyl-CoA cyclohexa-1,5-dienecarbonyl-CoA + H2O

Hence, this enzyme has one substrate, 6-hydroxycyclohex-1-enecarbonyl-CoA, and two products, cyclohexa-1,5-dienecarbonyl-CoA and H2O.

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is 6-hydroxycyclohex-1-enecarbonyl-CoA (cyclohexa-1,5-dienecarbonyl-CoA-forming). Other names in common use include cyclohexa-1,5-diene-1-carbonyl-CoA hydratase, dienoyl-CoA hydratase, and cyclohexa-1,5-dienecarbonyl-CoA hydro-lyase (incorrect). This enzyme participates in benzoate degradation via coa ligation.

References

    • Laempe D, Eisenreich W, Bacher A, Fuchs G (1998). "Cyclohexa-1,5-diene-1-carbonyl-CoA hydratase [corrected], an enzyme involved in anaerobic metabolism of benzoyl-CoA in the denitrifying bacterium Thauera aromatica". Eur. J. Biochem. 255 (3): 618&ndash, 27. doi:10.1046/j.1432-1327.1998.2550618.x. PMID 9738901.
    • Harwood CS, Gibson J (1997). "Shedding light on anaerobic benzene ring degradation: a process unique to prokaryotes?". J. Bacteriol. 179 (2): 301&ndash, 9. PMC 178697. PMID 8990279.
    • Koch J, Eisenreich W, Bacher A, Fuchs G (1993). "Products of enzymatic reduction of benzoyl-CoA, a key reaction in anaerobic aromatic metabolism". Eur. J. Biochem. 211 (3): 649&ndash, 61. doi:10.1111/j.1432-1033.1993.tb17593.x. PMID 8436125.


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