Plasma kallikrein

Plasma kallikrein
Identifiers
EC number 3.4.21.34
CAS number 410538-33-9
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Plasma kallikrein (EC 3.4.21.34, serum kallikrein, kininogenin, kallikrein I, kallikrein II, kininogenase, kallikrein, callicrein, glumorin, padreatin, padutin, kallidinogenase, bradykininogenase, panceatic kallikrein, onokrein P, dilminal D, depot-Padutin, urokallikrein, urinary kallikrein) is an enzyme.[1][2][3][4][5] This enzyme catalyses the following chemical reaction

Selective cleavage of some Arg- and Lys- bonds, including Lys-Arg and Arg-Ser in (human) kininogen to release bradykinin

This enzyme is formed from plasma prokallikrein (Fletcher factor) by factor XIIa.

See also

References

  1. ↑ Heimark RL, Davie EW (1981). "Bovine and human plasma prekallikrein". Methods in Enzymology. 80 Pt C: 157–72. doi:10.1016/s0076-6879(81)80016-x. PMID 6918767.
  2. ↑ McRae BJ, Kurachi K, Heimark RL, Fujikawa K, Davie EW, Powers JC (December 1981). "Mapping the active sites of bovine thrombin, factor IXa, factor Xa, factor XIa, factor XIIa, plasma kallikrein, and trypsin with amino acid and peptide thioesters: development of new sensitive substrates". Biochemistry. 20 (25): 7196–206. doi:10.1021/bi00528a022. PMID 6976185.
  3. ↑ Silverberg M, Kaplan AP (1988). "Prekallikrein". Methods in Enzymology. 163: 85–95. doi:10.1016/0076-6879(88)63010-2. PMID 3237096.
  4. ↑ Seidah NG, Ladenheim R, Mbikay M, Hamelin J, Lutfalla G, Rougeon F, Lazure C, Chrétien M (October 1989). "The cDNA structure of rat plasma kallikrein". Dna. 8 (8): 563–74. doi:10.1089/dna.1989.8.563. PMID 2598771.
  5. ↑ Tsuda Y, Teno N, Okada Y, Wanaka K, Bohgaki M, Hijikata-Okunomiya A, Okamoto U, Naito T, Okamoto S (November 1989). "Synthesis of tripeptide chloromethyl ketones and examination of their inhibitory effects on plasmin and plasma kallikrein". Chemical & Pharmaceutical Bulletin. 37 (11): 3108–11. doi:10.1248/cpb.37.3108. PMID 2534361.
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