EAF1

EAF1
Identifiers
Aliases	EAF1, ELL associated factor 1
External IDs	MGI: 1921677 HomoloGene: 12561 GeneCards: EAF1
Gene location (Human)
Chr.	Chromosome 3 (human)[1]
End	15,450,635 bp[1]
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)[2]
End	31,509,858 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• protein binding;
Cellular component	• Cajal body; • nuclear speck; • transcription elongation factor complex; • ELL-EAF complex; • intracellular membrane-bounded organelle; • intercellular bridge; • cell nucleus; • nucleoplasm; • nuclear body;
Biological process	• regulation of transcription, DNA-templated; • transcription, DNA-templated; • transcription from RNA polymerase II promoter; • transcription elongation from RNA polymerase II promoter;
	Sources:Amigo / QuickGO
Orthologs
	85403
	74427
	ENSG00000144597
	ENSMUSG00000021890
	Q96JC9
	Q9D4C5
	NM_033083
	NM_028932
	NP_149074
	NP_083208
	Wikidata
View/Edit Human	View/Edit Mouse

ELL-associated factor 1 is a protein that in humans is encoded by the EAF1 gene.^[5]^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000144597 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021890 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Simone F, Polak PE, Kaberlein JJ, Luo RT, Levitan DA, Thirman MJ (July 2001). "EAF1, a novel ELL-associated factor that is delocalized by expression of the MLL-ELL fusion protein". Blood. 98 (1): 201–9. doi:10.1182/blood.V98.1.201. PMID 11418481.
↑ "Entrez Gene: EAF1 ELL associated factor 1".

Polak PE, Simone F, Kaberlein JJ, Luo RT, Thirman MJ (April 2003). "ELL and EAF1 are Cajal body components that are disrupted in MLL-ELL leukemia". Molecular Biology of the Cell. 14 (4): 1517–28. doi:10.1091/mbc.E02-07-0394. PMC 153119. PMID 12686606.
Kong SE, Banks CA, Shilatifard A, Conaway JW, Conaway RC (July 2005). "ELL-associated factors 1 and 2 are positive regulators of RNA polymerase II elongation factor ELL". Proceedings of the National Academy of Sciences of the United States of America. 102 (29): 10094–8. doi:10.1073/pnas.0503017102. PMC 1177379. PMID 16006523.
Xiao W, Jiang F, Wang Z (January 2006). "ELL binding regulates U19/Eaf2 intracellular localization, stability, and transactivation". The Prostate. 66 (1): 1–12. doi:10.1002/pros.20309. PMID 16114057.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Jiang F, Ai J, Xiao W, Wang Z (August 2007). "FB1, an E2A fusion partner in childhood leukemia, interacts with U19/EAF2 and inhibits its transcriptional activity". Cancer Letters. 253 (2): 265–72. doi:10.1016/j.canlet.2007.02.003. PMC 1989770. PMID 17395368.

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