Dynein, axonemal, heavy chain 14

DNAH14
Identifiers
Aliases	DNAH14, C1orf67, Dnahc14, HL-18, HL18, dynein axonemal heavy chain 14
External IDs	MGI: 2444525 HomoloGene: 90078 GeneCards: DNAH14
Gene location (Human)
Chr.	Chromosome 1 (human)[1]
End	225,399,292 bp[1]
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)[2]
End	181,815,774 bp[2]
Gene ontology
Molecular function	• microtubule motor activity; • nucleotide binding; • motor activity; • ATP binding; • ATP-dependent microtubule motor activity, minus-end-directed; • dynein light chain binding; • dynein intermediate chain binding; • dynein light intermediate chain binding;
Cellular component	• cytoplasm; • cell projection; • microtubule; • cytoskeleton; • cilium; • dynein complex;
Biological process	• microtubule-based movement; • cilium morphogenesis;
	Sources:Amigo / QuickGO
Orthologs
	127602
	240960
	ENSG00000185842
	ENSMUSG00000047369
	Q0VDD8
	n/a
	NM_001145154; NM_001373; NM_144989; NM_001349911; NM_001349912
	NM_172846
	NP_001138626; NP_001364; NP_659426; NP_001336840; NP_001336841
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Dynein, axonemal, heavy chain 14 is a protein that in humans is encoded by the DNAH14 gene.^[5]

Function

Dyneins are microtubule-associated motor protein complexes composed of several heavy, light, and intermediate chains. Two major classes of dyneins, axonemal and cytoplasmic, have been identified. DNAH14 is an axonemal dynein heavy chain (DHC) (Vaughan et al., 1996 [PubMed 8812413]).^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000185842 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000047369 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ "Entrez Gene: Dynein, axonemal, heavy chain 14".
↑ Vaughan KT, Mikami A, Paschal BM, Holzbaur EL, Hughes SM, Echeverri CJ, Moore KJ, Gilbert DJ, Copeland NG, Jenkins NA, Vallee RB (August 1996). "Multiple mouse chromosomal loci for dynein-based motility". Genomics. 36 (1): 29–38. doi:10.1006/geno.1996.0422. PMID 8812413.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000185842 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000047369 - Ensembl, May 2017

[3] "Human PubMed Reference:".

[4] "Mouse PubMed Reference:".

[entrez-5] "Entrez Gene: Dynein, axonemal, heavy chain 14".

[6] Vaughan KT, Mikami A, Paschal BM, Holzbaur EL, Hughes SM, Echeverri CJ, Moore KJ, Gilbert DJ, Copeland NG, Jenkins NA, Vallee RB (August 1996). "Multiple mouse chromosomal loci for dynein-based motility". Genomics. 36 (1): 29–38. doi:10.1006/geno.1996.0422. PMID 8812413.