Douglas R. Green

Douglas R. Green
Born Douglas R Green
February 1955 (age 63)
United States
Nationality United States
Known for apoptosis research
Scientific career
Fields Cell Death, Cancer Biology, Immunology
Institutions St. Jude Children's Research Hospital
Website www.stjude.org/green

Douglas Green (born 1955), is an American biologist. He holds the Peter C. Doherty Endowed Chair of Immunology in St. Jude Children's Research Hospital. Green received his PhD from Yale.

His research has focused on the process of active cell death and cell survival, extending from the role of cell death in cancer regulation and immune responses in the whole organism to the fundamental molecular events directing the death of the cell. Green is editor in chief of the Nature Publishing Group journal Oncogene (journal). He is the author of the book Cell Death, Means To An End.[1]

Education

Green attended high school in Ashland, MA. He graduated magna cum laude from the Yale University with a Bachelor of Science in Biology and Distinction in Biology in 1977. After training at MIT during 1977 and 1978, he graduated in 1981 with a PhD from Yale University, where he studied immunology with Richard K. Gershon.[2][3]

He joined the faculty at the University of Alberta in Edmonton in 1989, and in 1990 became Member and Head of the Division of Cellular Immunology at the La Jolla Institute for Allergy and Immunology in San Diego, where he worked until 2005. He was adjunct of the University of California, San Diego from 1994 to 2005. He became chair of Immunology of St. Jude Children's Research Hospital, Memphis in 2005.

Research

After many studies on immunological tolerance, Green's work on cell death began with his discovery of activation-induced apoptosis in T lymphocytes,[4][5] the role of c-Myc in this process[6] and the finding that Bcl-2 cooperates with Myc in oncogenesis by blocking apoptosis.[7] More recently, he discovered the process of LC3-associated phagocytosis, which links the autophagy pathway to phagosome maturation.[8] Other areas of interest include regulated necrosis,[9] metabolic reprogramming in T lymphocytes,[10] and the function of the tumor suppressor, p53.[11] As of 2014 he had published many chapters and books and over 500 papers, making him one of the world's most cited molecular biologists.[12] He is listed in:

  • ISI "highly cited" (Immunology 2003)
  • ISI "highly cited" (Molecular Biology/Genetics 2014)

Recognition

Green has received many awards, among these the E.J. Boell Award (Biology) (Yale, 1977), the J.S. Nicholas Award (Zoology) (Yale, 1981), Alberta Heritage Scholar (AHFMR 1985-1990), the Outstanding Teacher Award (Alberta, 1990), Ashland Public School System Hall of Fame[13] (Ashland, MA 1998), MERIT Award, NIGMS (2002), the International Cell Death Society Prize[14] (2009), Einstein Professorship (China, 2011). He is an Honorary Fellow of Trinity College, Dublin (2010)[15] and Dottore Honoris Causa of Rome University Tor Vergata (2016)[16]

References

  1. ↑ Green, Douglas (2011). Means To An End. New York: Cold Spring Harbor Laboratory Press. ISBN 978-0-87969-887-4.
  2. ↑ Green, D. R.; Gold, J; St Martin, S; Gershon, R; Gershon, R. K. (1982). "Microenvironmental immunoregulation: Possible role of contrasuppressor cells in maintaining immune responses in gut-associated lymphoid tissues". Proceedings of the National Academy of Sciences of the United States of America. 79 (3): 889–92. doi:10.1073/pnas.79.3.889. PMC 345858. PMID 6461009.
  3. ↑ Green, D. R.; Flood, P. M.; Gershon, R. K. (1983). "Immunoregulatory T-cell pathways". Annual Review of Immunology. 1: 439–63. doi:10.1146/annurev.iy.01.040183.002255. PMID 6152712.
  4. ↑ Shi, Y. F.; Sahai, B. M.; Green, D. R. (1989). "Cyclosporin a inhibits activation-induced cell death in T-cell hybridomas and thymocytes". Nature. 339 (6226): 625–6. doi:10.1038/339625a0. PMID 2786609.
  5. ↑ Shi, Y. F.; Szalay, M. G.; Paskar, L; Sahai, B. M.; Boyer, M; Singh, B; Green, D. R. (1990). "Activation-induced cell death in T cell hybridomas is due to apoptosis. Morphologic aspects and DNA fragmentation". Journal of Immunology. 144 (9): 3326–33. PMID 1691753.
  6. ↑ Shi, Y; Glynn, J. M.; Guilbert, L. J.; Cotter, T. G.; Bissonnette, R. P.; Green, D. R. (1992). "Role for c-myc in activation-induced apoptotic cell death in T cell hybridomas". Science. 257 (5067): 212–4. doi:10.1126/science.1378649. PMID 1378649.
  7. ↑ Bissonnette, R. P.; Echeverri, F; Mahboubi, A; Green, D. R. (1992). "Apoptotic cell death induced by c-myc is inhibited by bcl-2". Nature. 359 (6395): 552–4. doi:10.1038/359552a0. PMID 1406975.
  8. ↑ Sanjuan, M. A.; Dillon, C. P.; Tait, S. W.; Moshiach, S; Dorsey, F; Connell, S; Komatsu, M; Tanaka, K; Cleveland, J. L.; Withoff, S; Green, D. R. (2007). "Toll-like receptor signalling in macrophages links the autophagy pathway to phagocytosis". Nature. 450 (7173): 1253–7. doi:10.1038/nature06421. PMID 18097414.
  9. ↑ Dillon, C. P.; Weinlich, R; Rodriguez, D. A.; Cripps, J. G.; Quarato, G; Gurung, P; Verbist, K. C.; Brewer, T. L.; Llambi, F; Gong, Y. N.; Janke, L. J.; Kelliher, M. A.; Kanneganti, T. D.; Green, D. R. (2014). "RIPK1 blocks early postnatal lethality mediated by caspase-8 and RIPK3". Cell. 157 (5): 1189–202. doi:10.1016/j.cell.2014.04.018. PMC 4068710. PMID 24813850.
  10. ↑ Wang, R; Dillon, C. P.; Shi, L. Z.; Milasta, S; Carter, R; Finkelstein, D; McCormick, L. L.; Fitzgerald, P; Chi, H; Munger, J; Green, D. R. (2011). "The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation". Immunity. 35 (6): 871–82. doi:10.1016/j.immuni.2011.09.021. PMC 3248798. PMID 22195744.
  11. ↑ Chipuk, J. E.; Kuwana, T; Bouchier-Hayes, L; Droin, N. M.; Newmeyer, D. D.; Schuler, M; Green, D. R. (2004). "Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis". Science. 303 (5660): 1010–4. doi:10.1126/science.1092734. PMID 14963330.
  12. ↑ "ISI - highlycited.com". Retrieved 2015-02-06.
  13. ↑ Hall of Fame
  14. ↑ International Cell Death Society Prize Archived February 25, 2015, at the Wayback Machine.
  15. ↑ Trinity College Fellows Scholars 2010
  16. ↑ Dottorato Honoris Causa in 'Biochimica e Biologia Molecolare' a Douglas R. Green
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