Dean Ho (biomedical engineer)

Dean Ho is a Provost’s Chair Professor in the Departments of Biomedical Engineering and Pharmacology, and Director of SINAPSE at the National University of Singapore. He is also a member of the Biomedical Institute for Global Health Research and Technology (BIGHEART). He was previously a Professor at UCLA, and Associate Professor in the Departments of Biomedical Engineering and Mechanical Engineering in the Robert R. McCormick School of Engineering and Applied Science, and Full Member of the Robert H. Lurie Comprehensive Cancer Center at the Feinberg School of Medicine of Northwestern University, Illinois, United States.

Research

Dr. Ho's research has covered emerging areas of nanomedicine and nanodiamond-based drug delivery. Dr. Ho and his colleagues were the first to develop nanodiamond platforms for cancer therapy and wound healing, among other areas. Dr. Ho and colleagues were the first to demonstrate the translational potential of nanodiamonds as chemotherapeutic delivery agents, specifically towards the treatment of drug-resistant cancers in vivo.[1] This work was published as the Cover Article of the March 9 issue of the journal Science Translational Medicine.[2] Dr. Ho is also leading 2 clinical trials to validate nanodiamond-embedded biomaterial devices for wound healing and the prevention of re-infection.[3][4] He has also developed nanodiamond-functionalized biomaterials for other clinically-relevant applications.

Dr. Ho is also known for his work in the areas of artificial intelligence (AI) and its application towards personalized and precision medicine. His team and colleagues pioneered the field of Augmented AI (CURATE.AI), which mediates model-free and mechanism-independent N-of-1 combination therapy and rapidly accelerated and globally optimized drug development. This has led to multiple clinical trials that have validated the CURATE.AI platform.[5][6] This AI platform has realized best-in-class medicines for population-wide administration, as well as the unprecedented ability to actionably personalize treatment for the entire duration of care on a patient-specific basis.[7] Dr. Ho's extensive research achievements have garnered news coverage in The Economist,[8] Forbes,[9] Nature (journal), CNN,[10] NPR, as well as The Washington Post. He was also featured in the National Geographic Channel program, Known Universe.[11] Most recently, the Augmented AI platform was featured by FuturizeX, a partnership between the X PRIZE Foundation and UCLA.[12] Recent clinical advances using this AI approach to enhance clinical outcomes were recognized among the finalists for the SLAS Innovation Award, selection among the SLAS Technology 10, and InnovFest Unbound.[13][14]

Previously, Dr. Ho served the Editor-in-Chief of the Journal of Laboratory Automation, now known as SLAS Technology. He also served as the President of the Board of Directors of the Society for Laboratory Automation and Screening which is a 20,000+ member drug development and life sciences technology organization. Dr. Ho is a recipient of the National Science Foundation CAREER Award, Wallace H. Coulter Foundation Translational Research Award, V Foundation for Cancer Research V Scholar Award, John G. Bollinger Outstanding Young Manufacturing Engineering Award of the Society of Manufacturing Engineers, UCLA School of Engineering and Applied Science Distinguished Young Alumnus Award, IADR William J. Gies Award, and IADR Young Investigator Award.[15][16] He is a Fellow of the American Institute for Medical and Biological Engineering (AIMBE), and the Society for Laboratory Automation and Screening (SLAS).[17] He was also named to the 2016 Power List of The Pathologist Magazine.[18]

See also

References

  1. ↑ https://www.npr.org/sections/health-shots/2011/07/22/134369404/could-diamonds-become-an-oncologists-best-friend
  2. ↑ E.Chow, X. Zhang, M. Chen, R. Lam, E. Robinson, H. Huang, D. Schaffer, E. Osawa, A. Goga, and D. Ho, Nanodiamond Therapeutic Delivery Agent Mediate Enhanced Chemoresistant Tumor Treatment, Science Translational Medicine, 2011, 73ra21.
  3. ↑ https://directorsblog.nih.gov/2017/10/31/nanodiamonds-shine-in-root-canal-study/
  4. ↑ https://www.washingtonpost.com/national/health-science/nanodiamonds-may-make-for-better-root-canals/2015/10/26/3b4fa392-781c-11e5-b9c1-f03c48c96ac2_story.html
  5. ↑ http://newsroom.ucla.edu/releases/ucla-study-yields-the-key-to-effective-personalized-medicine
  6. ↑ https://www.statnews.com/2016/04/06/tailoring-dosages-patients/
  7. ↑ A. Zarrinpar, D.Lee, A. Silva, N. Datta, T. Kee, C. Eriksen, K. Weigle, V. Agopian, F. Kaldas, D. Farmer, S. Wang, R. Busuttil, C. Ho, and D. Ho, Individualizing liver transplant immunosuppression using a phenotypic personalized medicine platform, Science Translational Medicine, 2016, 333ra49.
  8. ↑ https://www.economist.com/news/science-and-technology/21677190-adding-tiny-gems-may-make-root-canal-treatment-more-effective-tooth-fairy-dust
  9. ↑ https://www.forbes.com/sites/sujatakundu/2015/11/29/nanodiamonds-found-to-strengthen-dental-fillings-and-reduce-tooth-infection/#242990f85ca4
  10. ↑ http://www.cnn.com/2007/TECH/science/10/19/nanodiamonds.drugs/index.html
  11. ↑ https://www.imdb.com/name/nm3623992/
  12. ↑ http://futurizex.ucla.edu/medicine-tailored-to-you/
  13. ↑ http://innovfestunbound.com/innovfest-unbound/profile/83060/dean-ho
  14. ↑ http://www.slas2017.org/awards/innovationAward-finalists.cfm
  15. ↑ http://www.iadr.com/m/pages.cfm?pageID=3429
  16. ↑ http://www.iadr.org/i4a/pages/index.cfm?pageID=4878#.WJnY4LYrLaZ
  17. ↑ https://www.slas.org/eln/nanodiamonds-battling-cancer-the-new-slas-endowed-fellowship-at-ucla/
  18. ↑ https://thepathologist.com/power-list/2016/
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