Daprodustat

Daprodustat
Clinical data
Synonyms	GSK1278863
ATC code	None;
Identifiers
	IUPAC name 2-[(1,3-dicyclohexyl-2,4,6-trioxo-1,3-diazinane-5-carbonyl)amino]acetic acid;
CAS Number	960539-70-2;
PubChem CID	91617630;
Chemical and physical data
Formula	C19H27N3O6
Molar mass	393.44 g/mol
3D model (JSmol)	Interactive image;
	SMILES C3CCCCC3n(c(=O)c1C(=O)NCC(=O)O)c(=O)n(c1O)C2CCCCC2;

Daprodustat (INN) (GSK1278863) is a drug which acts as a HIF prolyl-hydroxylase inhibitor and thereby increases endogenous production of erythropoietin, which stimulates production of hemoglobin and red blood cells. It is in Phase III clinical trials for the treatment of anemia secondary to chronic kidney disease.^[1]^[2] Due to its potential applications in athletic doping, it has also been incorporated into screens for performance-enhancing drugs.^[3]

References

↑ Schmid H, Jelkmann W. Investigational therapies for renal disease-induced anemia. Expert Opin Investig Drugs. 2016 Aug;25(8):901-16. . doi:10.1080/13543784.2016.1182981. PMID 27122198. Missing or empty |title= (help)
↑ Ariazi JL, Duffy KJ, Adams DF, Fitch DM, Luo L, Pappalardi M, Biju M, DiFilippo EH, Shaw T, Wiggall K, Erickson-Miller C. Discovery and Preclinical Characterization of GSK1278863 (Daprodustat), a Small Molecule Hypoxia Inducible Factor-Prolyl Hydroxylase Inhibitor for Anemia. J Pharmacol Exp Ther. 2017 Dec;363(3):336-347. . doi:10.1124/jpet.117.242503. PMID 28928122. Missing or empty |title= (help)
↑ Thevis M, Milosovich S, Licea-Perez H, Knecht D, Cavalier T, Schänzer W. Mass spectrometric characterization of a prolyl hydroxylase inhibitor GSK1278863, its bishydroxylated metabolite, and its implementation into routine doping controls. Drug Test Anal. 2016 Aug;8(8):858-63. . doi:10.1002/dta.1870. PMID 26361079. Missing or empty |title= (help)

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