DRAP1

DRAP1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesDRAP1, NC2-alpha, DR1 associated protein 1
External IDsMGI: 1913806 HomoloGene: 4703 GeneCards: DRAP1
Gene location (Human)
Chr.Chromosome 11 (human)[1]
Band11q13.1Start65,919,257 bp[1]
End65,921,561 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

10589

66556

Ensembl

ENSG00000175550

ENSMUSG00000024914

UniProt

Q14919

Q9D6N5

RefSeq (mRNA)

NM_006442

NM_001291080
NM_024176

RefSeq (protein)

NP_006433

NP_001278009
NP_077138

Location (UCSC)Chr 11: 65.92 – 65.92 MbChr 19: 5.42 – 5.42 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Dr1-associated corepressor is a protein that in humans is encoded by the DRAP1 gene.[5][6]

Transcriptional repression is a general mechanism for regulating transcriptional initiation in organisms ranging from yeast to humans. Accurate initiation of transcription from eukaryotic protein-encoding genes requires the assembly of a large multiprotein complex consisting of RNA polymerase II and general transcription factors such as TFIIA, TFIIB, and TFIID. DR1 is a repressor that interacts with the TATA-binding protein (TBP) of TFIID and prevents the formation of an active transcription complex by precluding the entry of TFIIA and/or TFIIB into the preinitiation complex. The protein encoded by this gene is a corepressor of transcription that interacts with DR1 to enhance DR1-mediated repression. The interaction between this corepressor and DR1 is required for corepressor function and appears to stabilize the TBP-DR1-DNA complex.[6]

Interactions

DRAP1 has been shown to interact with FOXH1[7] and DR1.[8][9]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000175550 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024914 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Mermelstein F, Yeung K, Cao J, Inostroza JA, Erdjument-Bromage H, Eagelson K, Landsman D, Levitt P, Tempst P, Reinberg D (May 1996). "Requirement of a corepressor for Dr1-mediated repression of transcription". Genes Dev. 10 (8): 1033–48. doi:10.1101/gad.10.8.1033. PMID 8608938.
  6. 1 2 "Entrez Gene: DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha)".
  7. ↑ Iratni, Rabah; Yan Yu-Ting; Chen Canhe; Ding Jixiang; Zhang Yi; Price Sandy M; Reinberg Danny; Shen Michael M (Dec 2002). "Inhibition of excess nodal signaling during mouse gastrulation by the transcriptional corepressor DRAP1". Science. United States. 298 (5600): 1996–9. Bibcode:2002Sci...298.1996I. doi:10.1126/science.1073405. PMID 12471260.
  8. ↑ Mermelstein, F; Yeung K; Cao J; Inostroza J A; Erdjument-Bromage H; Eagelson K; Landsman D; Levitt P; Tempst P; Reinberg D (Apr 1996). "Requirement of a corepressor for Dr1-mediated repression of transcription". Genes Dev. UNITED STATES. 10 (8): 1033–48. doi:10.1101/gad.10.8.1033. ISSN 0890-9369. PMID 8608938.
  9. ↑ Yeung, K; Kim S; Reinberg D (Jan 1997). "Functional dissection of a human Dr1-DRAP1 repressor complex". Mol. Cell. Biol. UNITED STATES. 17 (1): 36–45. ISSN 0270-7306. PMC 231727. PMID 8972183.

Further reading

  • Goppelt A, Stelzer G, Lottspeich F, Meisterernst M (1996). "A mechanism for repression of class II gene transcription through specific binding of NC2 to TBP-promoter complexes via heterodimeric histone fold domains". EMBO J. 15 (12): 3105–16. PMC 450253. PMID 8670811.
  • Yeung K, Kim S, Reinberg D (1997). "Functional dissection of a human Dr1-DRAP1 repressor complex". Mol. Cell. Biol. 17 (1): 36–45. PMC 231727. PMID 8972183.
  • Ikeda K, Halle JP, Stelzer G, et al. (1998). "Involvement of negative cofactor NC2 in active repression by zinc finger-homeodomain transcription factor AREB6". Mol. Cell. Biol. 18 (1): 10–8. doi:10.1128/mcb.18.1.10. PMC 121442. PMID 9418848.
  • Castaño E, Gross P, Wang Z, et al. (2000). "The C-terminal domain-phosphorylated IIO form of RNA polymerase II is associated with the transcription repressor NC2 (Dr1/DRAP1) and is required for transcription activation in human nuclear extracts". Proc. Natl. Acad. Sci. U.S.A. 97 (13): 7184–9. Bibcode:2000PNAS...97.7184C. doi:10.1073/pnas.140202297. PMC 16520. PMID 10852970.
  • Kamada K, Shu F, Chen H, et al. (2001). "Crystal structure of negative cofactor 2 recognizing the TBP-DNA transcription complex". Cell. 106 (1): 71–81. doi:10.1016/S0092-8674(01)00417-2. PMID 11461703.
  • Iratni R, Yan YT, Chen C, et al. (2003). "Inhibition of excess nodal signaling during mouse gastrulation by the transcriptional corepressor DRAP1". Science. 298 (5600): 1996–9. Bibcode:2002Sci...298.1996I. doi:10.1126/science.1073405. PMID 12471260.
  • Denko N, Wernke-Dollries K, Johnson AB, et al. (2003). "Hypoxia actively represses transcription by inducing negative cofactor 2 (Dr1/DrAP1) and blocking preinitiation complex assembly". J. Biol. Chem. 278 (8): 5744–9. doi:10.1074/jbc.M212534200. PMID 12477712.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Leonard D, Ajuh P, Lamond AI, Legerski RJ (2003). "hLodestar/HuF2 interacts with CDC5L and is involved in pre-mRNA splicing". Biochem. Biophys. Res. Commun. 308 (4): 793–801. doi:10.1016/S0006-291X(03)01486-4. PMID 12927788.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Klejman MP, Pereira LA, van Zeeburg HJ, et al. (2004). "NC2alpha interacts with BTAF1 and stimulates its ATP-dependent association with TATA-binding protein". Mol. Cell. Biol. 24 (22): 10072–82. doi:10.1128/MCB.24.22.10072-10082.2004. PMC 525489. PMID 15509807.
  • Lewis BA, Sims RJ, Lane WS, Reinberg D (2005). "Functional characterization of core promoter elements: DPE-specific transcription requires the protein kinase CK2 and the PC4 coactivator". Mol. Cell. 18 (4): 471–81. doi:10.1016/j.molcel.2005.04.005. PMID 15893730.
  • Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514.
  • Assmann EM, Alborghetti MR, Camargo ME, Kobarg J (2006). "FEZ1 dimerization and interaction with transcription regulatory proteins involves its coiled-coil region". J. Biol. Chem. 281 (15): 9869–81. doi:10.1074/jbc.M513280200. PMID 16484223.
  • Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
  • Albert TK, Grote K, Boeing S, et al. (2007). "Global distribution of negative cofactor 2 subunit-alpha on human promoters". Proc. Natl. Acad. Sci. U.S.A. 104 (24): 10000–5. Bibcode:2007PNAS..10410000A. doi:10.1073/pnas.0703490104. PMC 1891239. PMID 17548813.


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