DPYSL5

DPYSL5
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesDPYSL5, CRAM, CRMP-5, CRMP5, Ulip6, dihydropyrimidinase like 5
External IDsMGI: 1929772 HomoloGene: 41347 GeneCards: DPYSL5
Gene location (Human)
Chr.Chromosome 2 (human)[1]
Band2p23.3Start26,847,747 bp[1]
End26,950,351 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

56896

65254

Ensembl

ENSG00000157851

ENSMUSG00000029168

UniProt

Q9BPU6

Q9EQF6

RefSeq (mRNA)

NM_020134
NM_001253723
NM_001253724

NM_023047
NM_001356948
NM_001356949

RefSeq (protein)

NP_001240652
NP_001240653
NP_064519

NP_075534
NP_001343877
NP_001343878

Location (UCSC)Chr 2: 26.85 – 26.95 MbChr 5: 30.71 – 30.8 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Dihydropyrimidinase-related protein 5 is an enzyme that in humans is encoded by the DPYSL5 gene.[5][6][7]

Members of the CRMP family, such as DPYSL5, are believed to play a role in growth cone guidance during neural development.[supplied by OMIM][7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000157851 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029168 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Inatome R, Tsujimura T, Hitomi T, Mitsui N, Hermann P, Kuroda S, Yamamura H, Yanagi S (Oct 2000). "Identification of CRAM, a novel unc-33 gene family protein that associates with CRMP3 and protein-tyrosine kinase(s) in the developing rat brain". J Biol Chem. 275 (35): 27291–302. doi:10.1074/jbc.M910126199. PMID 10851247.
  6. ↑ Horiuchi M, El Far O, Betz H (Nov 2000). "Ulip6, a novel unc-33 and dihydropyrimidinase related protein highly expressed in developing rat brain". FEBS Lett. 480 (2–3): 283–6. doi:10.1016/S0014-5793(00)01952-9. PMID 11034345.
  7. 1 2 "Entrez Gene: DPYSL5 dihydropyrimidinase-like 5".

Further reading

  • Cross SA, Salomao DR, Parisi JE, et al. (2003). "Paraneoplastic autoimmune optic neuritis with retinitis defined by CRMP-5-IgG". Ann. Neurol. 54 (1): 38–50. doi:10.1002/ana.10587. PMID 12838519.
  • Fukada M, Watakabe I, Yuasa-Kawada J, et al. (2001). "Molecular characterization of CRMP5, a novel member of the collapsin response mediator protein family". J. Biol. Chem. 275 (48): 37957–65. doi:10.1074/jbc.M003277200. PMID 10956643.
  • Yu Z, Kryzer TJ, Griesmann GE, et al. (2001). "CRMP-5 neuronal autoantibody: marker of lung cancer and thymoma-related autoimmunity". Ann. Neurol. 49 (2): 146–54. doi:10.1002/1531-8249(20010201)49:2<146::AID-ANA34>3.0.CO;2-E. PMID 11220734.
  • Ricard D, Rogemond V, Charrier E, et al. (2001). "Isolation and expression pattern of human Unc-33-like phosphoprotein 6/collapsin response mediator protein 5 (Ulip6/CRMP5): coexistence with Ulip2/CRMP2 in Sema3a- sensitive oligodendrocytes". J. Neurosci. 21 (18): 7203–14. PMID 11549731.
  • Mitsui N, Inatome R, Takahashi S, et al. (2002). "Involvement of Fes/Fps tyrosine kinase in semaphorin3A signaling". EMBO J. 21 (13): 3274–85. doi:10.1093/emboj/cdf328. PMC 125392. PMID 12093729.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.


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