DPP9

DPP9
Identifiers
AliasesDPP9, DP9, DPLP9, DPRP-2, DPRP2, dipeptidyl peptidase 9
External IDsMGI: 2443967 HomoloGene: 16385 GeneCards: DPP9
Gene location (Human)
Chr.Chromosome 19 (human)[1]
Band19p13.3Start4,675,224 bp[1]
End4,724,673 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

91039

224897

Ensembl

ENSG00000142002

ENSMUSG00000001229

UniProt

Q86TI2

Q8BVG4

RefSeq (mRNA)

NM_139159

NM_172624
NM_001360284

RefSeq (protein)

NP_631898

NP_766212
NP_001347213

Location (UCSC)Chr 19: 4.68 – 4.72 MbChr 17: 56.19 – 56.22 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Dipeptidyl peptidase 9 is an enzyme that in humans is encoded by the DPP9 gene.[5]

This gene encodes a protein that is a member of the S9B family in clan SC of the serine proteases. The protein has been shown to have post-proline dipeptidyl aminopeptidase activity, cleaving Xaa-Pro dipeptides from the N-termini of proteins. Although the activity of this protein is similar to that of dipeptidyl peptidase 4 (DPP4), it does not appear to be membrane bound. In general, dipeptidyl peptidases appear to be involved in the regulation of the activity of their substrates and have been linked to a variety of diseases including type 2 diabetes, obesity and cancer. Several transcript variants of this gene have been described but not fully characterized.[5]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000142002 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000001229 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. 1 2 "Entrez Gene: DPP9 dipeptidyl-peptidase 9".

Further reading

  • Olsen C, Wagtmann N (2003). "Identification and characterization of human DPP9, a novel homologue of dipeptidyl peptidase IV". Gene. 299 (1–2): 185–93. doi:10.1016/S0378-1119(02)01059-4. PMID 12459266.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ajami K, Abbott CA, Obradovic M, et al. (2003). "Structural requirements for catalysis, expression, and dimerization in the CD26/DPIV gene family". Biochemistry. 42 (3): 694–701. doi:10.1021/bi026846s. PMID 12534281.
  • Qi SY, Riviere PJ, Trojnar J, et al. (2003). "Cloning and characterization of dipeptidyl peptidase 10, a new member of an emerging subgroup of serine proteases". Biochem. J. 373 (Pt 1): 179–89. doi:10.1042/BJ20021914. PMC 1223468. PMID 12662155.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Ajami K, Abbott CA, McCaughan GW, Gorrell MD (2004). "Dipeptidyl peptidase 9 has two forms, a broad tissue distribution, cytoplasmic localization and DPIV-like peptidase activity". Biochim. Biophys. Acta. 1679 (1): 18–28. doi:10.1016/j.bbaexp.2004.03.010. PMID 15245913.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Ogasawara W, Tanaka C, Suzuki M, et al. (2005). "Isoforms of dipeptidyl aminopeptidase IV from Pseudomonas sp. WO24: role of the signal sequence and overexpression in Escherichia coli". Protein Expr. Purif. 41 (2): 241–51. doi:10.1016/j.pep.2004.10.027. PMID 15866709.
  • Bjelke JR, Christensen J, Nielsen PF, et al. (2006). "Dipeptidyl peptidases 8 and 9: specificity and molecular characterization compared with dipeptidyl peptidase IV". Biochem. J. 396 (2): 391–9. doi:10.1042/BJ20060079. PMC 1462722. PMID 16475979.
  • Yu DM, Wang XM, Ajami K, et al. (2006). "DP8 and DP9 have extra-enzymatic roles in cell adhesion, migration and apoptosis". Adv. Exp. Med. Biol. Advances in Experimental Medicine and Biology. 575: 63–72. doi:10.1007/0-387-32824-6_7. ISBN 978-0-387-29058-4. PMID 16700509.
  • Yu DM, Wang XM, McCaughan GW, Gorrell MD (2006). "Extraenzymatic functions of the dipeptidyl peptidase IV-related proteins DP8 and DP9 in cell adhesion, migration and apoptosis". FEBS J. 273 (11): 2447–60. doi:10.1111/j.1742-4658.2006.05253.x. PMID 16704418.


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