DOM3Z

DXO
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesDXO, DOM3L, DOM3Z, NG6, RAI1, decapping exoribonuclease
External IDsMGI: 1890444 HomoloGene: 38061 GeneCards: DXO
Gene location (Human)
Chr.Chromosome 6 (human)[1]
Band6p21.33Start31,969,810 bp[1]
End31,972,292 bp[1]
RNA expression pattern




More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

1797

112403

Ensembl

ENSMUSG00000040482

UniProt

O77932

O70348

RefSeq (mRNA)

NM_005510

NM_001163770
NM_033613

RefSeq (protein)

NP_005501

NP_001157242
NP_291091

Location (UCSC)Chr 6: 31.97 – 31.97 MbChr 17: 34.84 – 34.84 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Protein Dom3Z is a protein that in humans is encoded by the DOM3Z gene.[5][6]

This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. The function of its protein product is unknown, but its ubiquitous expression and conservation in both simple and complex eukaryotes suggests that this may be a housekeeping gene.[6]

References

  1. 1 2 3 ENSG00000236765, ENSG00000224313, ENSG00000206346, ENSG00000225682, ENSG00000234798 GRCh38: Ensembl release 89: ENSG00000204348, ENSG00000236765, ENSG00000224313, ENSG00000206346, ENSG00000225682, ENSG00000234798 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000040482 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Yang Z, Shen L, Dangel AW, Wu LC, Yu CY (Dec 1998). "Four ubiquitously expressed genes, RD (D6S45)-SKI2W (SKIV2L)-DOM3Z-RP1 (D6S60E), are present between complement component genes factor B and C4 in the class III region of the HLA". Genomics. 53 (3): 338–47. doi:10.1006/geno.1998.5499. PMID 9799600.
  6. 1 2 "Entrez Gene: DOM3Z dom-3 homolog Z (C. elegans)".

Further reading

  • Yu CY (1999). "Molecular genetics of the human MHC complement gene cluster". Exp. Clin. Immunogenet. 15 (4): 213–30. doi:10.1159/000019075. PMID 10072631.
  • Yang Z, Yu CY (2000). "Organizations and gene duplications of the human and mouse MHC complement gene clusters". Exp. Clin. Immunogenet. 17 (1): 1–17. doi:10.1159/000019119. PMID 10686478.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
  • Xie T, Rowen L, Aguado B, et al. (2004). "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse". Genome Res. 13 (12): 2621–36. doi:10.1101/gr.1736803. PMC 403804. PMID 14656967.
  • Lehner B, Semple JI, Brown SE, et al. (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics. 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID 14667819.
  • Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.


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