DOC2A

DOC2A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4MJJ
Identifiers
Aliases	DOC2A, Doc2, double C2 domain alpha
External IDs	MGI: 109446 HomoloGene: 2657 GeneCards: DOC2A
Gene location (Human)
Chr.	Chromosome 16 (human)[1]
End	30,023,270 bp[1]
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)[2]
End	126,852,705 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• calcium-dependent phospholipid binding; • clathrin binding; • calcium ion binding; • syntaxin binding; • protein binding;
Cellular component	• neuron projection; • lysosome; • synapse; • synaptic vesicle membrane; • membrane; • cytoplasmic vesicle; • plasma membrane; • cell nucleus; • nucleolus; • cell junction; • exocytic vesicle; • extrinsic component of synaptic vesicle membrane;
Biological process	• nervous system development; • regulation of calcium ion-dependent exocytosis; • synaptic vesicle exocytosis; • exocytosis; • chemical synaptic transmission; • calcium ion-regulated exocytosis of neurotransmitter; • vesicle fusion;
	Sources:Amigo / QuickGO
Orthologs
	8448
	13446
	ENSG00000149927
	ENSMUSG00000052301
	Q14183
	Q7TNF0
	NM_001282062; NM_001282063; NM_001282068; NM_003586
	NM_010069
	NP_001268991; NP_001268992; NP_001268997; NP_003577
	NP_034199
	Wikidata
View/Edit Human	View/Edit Mouse

Double C2-like domain-containing protein alpha is a protein that in humans is encoded by the DOC2A gene.^[5]^[6]^[7]

There are at least two protein isoforms of the Double C2 protein, namely alpha (DOC2A) and beta (DOC2B), which contain two C2-like domains. DOC2A and DOC2B are encoded by different genes; these genes are at times confused with the unrelated DAB2 gene which was initially named DOC-2. DOC2A is mainly expressed in brain and is suggested to be involved in Ca(2+)-dependent neurotransmitter release.^[7]

Interactions

DOC2A has been shown to interact with UNC13B^[6]^[8] and UNC13A.^[9]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000149927 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000052301 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Orita S, Sasaki T, Naito A, Komuro R, Ohtsuka T, Maeda M, Suzuki H, Igarashi H, Takai Y (Feb 1995). "Doc2: a novel brain protein having two repeated C2-like domains". Biochem Biophys Res Commun. 206 (2): 439–48. doi:10.1006/bbrc.1995.1062. PMID 7826360.
1 2 Mochida S, Orita S, Sakaguchi G, Sasaki T, Takai Y (Oct 1998). "Role of the Doc2α–Munc13–1 interaction in the neurotransmitter release process". Proc Natl Acad Sci U S A. 95 (19): 11418–22. doi:10.1073/pnas.95.19.11418. PMC 21657. PMID 9736751.
1 2 "Entrez Gene: DOC2A double C2-like domains, alpha".
↑ Orita S, Naito A, Sakaguchi G, Maeda M, Igarashi H, Sasaki T, Takai Y (June 1997). "Physical and functional interactions of Doc2 and Munc13 in Ca2+-dependent exocytotic machinery". J. Biol. Chem. 272 (26): 16081–4. doi:10.1074/jbc.272.26.16081. PMID 9195900.
↑ "Protein unc-13 homolog A". UniProt.

Sakaguchi G, Orita S, Maeda M, Igarashi H, Takai Y (December 1995). "Molecular cloning of an isoform of Doc2 having two C2-like domains". Biochem. Biophys. Res. Commun. 217 (3): 1053–61. doi:10.1006/bbrc.1995.2876. PMID 8554557.
Verhage M, de Vries KJ, Røshol H, Burbach JP, Gispen WH, Südhof TC (March 1997). "DOC2 proteins in rat brain: complementary distribution and proposed function as vesicular adapter proteins in early stages of secretion". Neuron. 18 (3): 453–61. doi:10.1016/S0896-6273(00)81245-3. PMID 9115738.
Nagano F, Orita S, Sasaki T, Naito A, Sakaguchi G, Maeda M, Watanabe T, Kominami E, Uchiyama Y, Takai Y (November 1998). "Interaction of Doc2 with tctex-1, a light chain of cytoplasmic dynein. Implication in dynein-dependent vesicle transport". J. Biol. Chem. 273 (46): 30065–8. doi:10.1074/jbc.273.46.30065. PMID 9804756.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000149927 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000052301 - Ensembl, May 2017

[3] "Human PubMed Reference:".

[4] "Mouse PubMed Reference:".

[pmid7826360-5] Orita S, Sasaki T, Naito A, Komuro R, Ohtsuka T, Maeda M, Suzuki H, Igarashi H, Takai Y (Feb 1995). "Doc2: a novel brain protein having two repeated C2-like domains". Biochem Biophys Res Commun. 206 (2): 439–48. doi:10.1006/bbrc.1995.1062. PMID 7826360.

[pmid9736751-6] 1 2 Mochida S, Orita S, Sakaguchi G, Sasaki T, Takai Y (Oct 1998). "Role of the Doc2α–Munc13–1 interaction in the neurotransmitter release process". Proc Natl Acad Sci U S A. 95 (19): 11418–22. doi:10.1073/pnas.95.19.11418. PMC 21657. PMID 9736751.

[entrez-7] 1 2 "Entrez Gene: DOC2A double C2-like domains, alpha".

[pmid9195900-8] Orita S, Naito A, Sakaguchi G, Maeda M, Igarashi H, Sasaki T, Takai Y (June 1997). "Physical and functional interactions of Doc2 and Munc13 in Ca2+-dependent exocytotic machinery". J. Biol. Chem. 272 (26): 16081–4. doi:10.1074/jbc.272.26.16081. PMID 9195900.

[9] "Protein unc-13 homolog A". UniProt.

DOC2A

Interactions

References

Further reading