DNASE1L3

DNASE1L3
Identifiers
Aliases	DNASE1L3, DHP2, DNAS1L3, LSD, SLEB16, deoxyribonuclease I like 3, deoxyribonuclease 1 like 3
External IDs	MGI: 1314633 HomoloGene: 3630 GeneCards: DNASE1L3
Gene location (Human)
Chr.	Chromosome 3 (human)[1]
End	58,214,697 bp[1]
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)[2]
End	7,994,573 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• DNA binding; • calcium ion binding; • nuclease activity; • endonuclease activity; • endodeoxyribonuclease activity; • hydrolase activity; • deoxyribonuclease activity; • deoxyribonuclease I activity;
Cellular component	• extracellular region; • endoplasmic reticulum; • cell nucleus;
Biological process	• DNA metabolic process; • DNA catabolic process; • programmed cell death involved in cell development; • apoptotic process; • programmed cell death; • apoptotic DNA fragmentation; • DNA catabolic process, endonucleolytic; • neutrophil activation involved in immune response; • regulation of acute inflammatory response; • regulation of neutrophil mediated cytotoxicity;
	Sources:Amigo / QuickGO
Orthologs
	1776
	13421
	ENSG00000163687
	ENSMUSG00000025279
	Q13609
	O55070
	NM_004944; NM_001256560
	NM_007870
	NP_001243489; NP_004935
	NP_031896
	Wikidata
View/Edit Human	View/Edit Mouse

Deoxyribonuclease gamma is an enzyme that in humans is encoded by the DNASE1L3 gene.^[5]^[6]^[7]^[8]

This gene encodes a member of the DNase family. The protein hydrolyzes DNA, is not inhibited by actin, and mediates the breakdown of DNA during apoptosis. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.^[8]

Homozygosity for a null allele results in systemic lupus erythematosus.^[9]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000163687 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025279 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Rodriguez AM, Rodin D, Nomura H, Morton CC, Weremowicz S, Schneider MC (Sep 1997). "Identification, localization, and expression of two novel human genes similar to deoxyribonuclease I". Genomics. 42 (3): 507–13. doi:10.1006/geno.1997.4748. PMID 9205125.
↑ Baron WF, Pan CQ, Spencer SA, Ryan AM, Lazarus RA, Baker KP (Oct 1998). "Cloning and characterization of an actin-resistant DNase I-like endonuclease secreted by macrophages". Gene. 215 (2): 291–301. doi:10.1016/S0378-1119(98)00281-9. PMID 9714828.
↑ Shiokawa D, Hirai M, Tanuma S (Dec 2003). "cDNA cloning of human DNase gamma: chromosomal localization of its gene and enzymatic properties of recombinant protein". Apoptosis. 3 (2): 89–95. doi:10.1023/A:1009692807692. PMID 14646506.
1 2 "Entrez Gene: DNASE1L3 deoxyribonuclease I-like 3".
↑ Al-Mayouf, Sulaiman M; Sunker, Asma; Abdwani, Reem; Abrawi, Safiya Al; Almurshedi, Fathiya; Alhashmi, Nadia; Al Sonbul, Abdullah; Sewairi, Wafaa; Qari, Aliya; Abdallah, Eiman; Al-Owain, Mohammed; Al Motywee, Saleh; Al-Rayes, Hanan; Hashem, Mais; Khalak, Hanif; Al-Jebali, Latifa; Alkuraya, Fowzan S (2011). "Loss-of-function variant in DNASE1L3 causes a familial form of systemic lupus erythematosus". Nature Genetics. 43 (12): 1186–1188. doi:10.1038/ng.975. ISSN 1061-4036.

Tanuma S, Shiokawa D (1994). "Multiple forms of nuclear deoxyribonuclease in rat thymocytes". Biochem. Biophys. Res. Commun. 203 (2): 789–97. doi:10.1006/bbrc.1994.2252. PMID 8093058.
Zeng Z, Parmelee D, Hyaw H, et al. (1997). "Cloning and characterization of a novel human DNase". Biochem. Biophys. Res. Commun. 231 (2): 499–504. doi:10.1006/bbrc.1996.5923. PMID 9070308.
Shiokawa D, Tanuma S (2001). "Characterization of human DNase I family endonucleases and activation of DNase gamma during apoptosis". Biochemistry. 40 (1): 143–52. doi:10.1021/bi001041a. PMID 11141064.
Wilber A, Lu M, Schneider MC (2003). "Deoxyribonuclease I-like III is an inducible macrophage barrier to liposomal transfection". Mol. Ther. 6 (1): 35–42. doi:10.1006/mthe.2002.0625. PMID 12095301.
Boulares AH, Zoltoski AJ, Sherif ZA, et al. (2002). "The Poly(ADP-ribose) polymerase-1-regulated endonuclease DNAS1L3 is required for etoposide-induced internucleosomal DNA fragmentation and increases etoposide cytotoxicity in transfected osteosarcoma cells". Cancer Res. 62 (15): 4439–44. PMID 12154052.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Shiokawa D, Shika Y, Tanuma S (2003). "Identification of two functional nuclear localization signals in DNase gamma and their roles in its apoptotic DNase activity". Biochem. J. 376 (Pt 2): 377–81. doi:10.1042/BJ20030820. PMC 1223774. PMID 12943533.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Boulares AH, Ren T (2004). "Mechanism of acetaminophen-induced apoptosis in cultured cells: roles of caspase-3, DNA fragmentation factor, and the Ca2+ and Mg2+ endonuclease DNAS1L3". Basic Clin. Pharmacol. Toxicol. 94 (1): 19–29. doi:10.1111/j.1742-7843.2004.pto_940105.x. PMID 14725611.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Okamoto M, Okamoto N, Yashiro H, et al. (2005). "Involvement of DNase gamma in the resected double-strand DNA breaks in immunoglobulin genes". Biochem. Biophys. Res. Commun. 327 (1): 76–83. doi:10.1016/j.bbrc.2004.11.142. PMID 15629432.
Boulares H, Zoltoski A, Kandan S, et al. (2006). "Correlation between decreased sensitivity of the Daudi lymphoma cells to VP-16-induced apoptosis and deficiency in DNAS1L3 expression". Biochem. Biophys. Res. Commun. 341 (2): 653–62. doi:10.1016/j.bbrc.2006.01.014. PMID 16427601.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000163687 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025279 - Ensembl, May 2017

[3] "Human PubMed Reference:".

[4] "Mouse PubMed Reference:".

[pmid9205125-5] Rodriguez AM, Rodin D, Nomura H, Morton CC, Weremowicz S, Schneider MC (Sep 1997). "Identification, localization, and expression of two novel human genes similar to deoxyribonuclease I". Genomics. 42 (3): 507–13. doi:10.1006/geno.1997.4748. PMID 9205125.

[pmid9714828-6] Baron WF, Pan CQ, Spencer SA, Ryan AM, Lazarus RA, Baker KP (Oct 1998). "Cloning and characterization of an actin-resistant DNase I-like endonuclease secreted by macrophages". Gene. 215 (2): 291–301. doi:10.1016/S0378-1119(98)00281-9. PMID 9714828.

[pmid14646506-7] Shiokawa D, Hirai M, Tanuma S (Dec 2003). "cDNA cloning of human DNase gamma: chromosomal localization of its gene and enzymatic properties of recombinant protein". Apoptosis. 3 (2): 89–95. doi:10.1023/A:1009692807692. PMID 14646506.

[entrez-8] 1 2 "Entrez Gene: DNASE1L3 deoxyribonuclease I-like 3".

[Al-MayoufSunker2011-9] Al-Mayouf, Sulaiman M; Sunker, Asma; Abdwani, Reem; Abrawi, Safiya Al; Almurshedi, Fathiya; Alhashmi, Nadia; Al Sonbul, Abdullah; Sewairi, Wafaa; Qari, Aliya; Abdallah, Eiman; Al-Owain, Mohammed; Al Motywee, Saleh; Al-Rayes, Hanan; Hashem, Mais; Khalak, Hanif; Al-Jebali, Latifa; Alkuraya, Fowzan S (2011). "Loss-of-function variant in DNASE1L3 causes a familial form of systemic lupus erythematosus". Nature Genetics. 43 (12): 1186–1188. doi:10.1038/ng.975. ISSN 1061-4036.

DNASE1L3

References

Further reading