DIS3L2

DIS3L2
Identifiers
Aliases	DIS3L2, FAM6A, PRLMNS, hDIS3 like 3'-5' exoribonuclease 2
External IDs	MGI: 2442555 HomoloGene: 62417 GeneCards: DIS3L2
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q37.1 Start 231,961,245 bp[1] End 232,344,350 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 C5 Start 86,703,808 bp[2] End 87,050,095 bp[2]
Gene ontology Molecular function • 3'-5'-exoribonuclease activity • poly(U) RNA binding • metal ion binding • ribonuclease activity • protein binding • RNA binding • nuclease activity • exonuclease activity • hydrolase activity • magnesium ion binding Cellular component • cytoplasm • polysome • P-body • exosome (RNase complex) Biological process • miRNA catabolic process • nucleic acid phosphodiester bond hydrolysis • nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' • cell division • stem cell population maintenance • rRNA processing • cell cycle • mitotic sister chromatid separation • negative regulation of cell proliferation • RNA phosphodiester bond hydrolysis, exonucleolytic • RNA phosphodiester bond hydrolysis • nuclear-transcribed mRNA catabolic process, exonucleolytic • polyuridylation-dependent mRNA catabolic process • mitotic cell cycle • RNA catabolic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	129563	208718
Ensembl	ENSG00000144535	ENSMUSG00000053333
UniProt	Q8IYB7	Q8CI75
RefSeq (mRNA)	NM_001257281 NM_001257282 NM_152383	NM_001172157 NM_153530
RefSeq (protein)	NP_001244210 NP_001244211 NP_689596	NP_001165628 NP_705758
Location (UCSC)	Chr 2: 231.96 – 232.34 Mb	Chr 1: 86.7 – 87.05 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

DIS3 mitotic control homolog (S. cerevisiae)-like 2 is a protein in humans that is encoded by the DIS3L2 gene. ^[5]

The protein encoded by this gene is similar in sequence to 3'/5' exonucleolytic subunits of the RNA exosome. The exosome is a large multimeric ribonucleotide complex responsible for degrading various RNA substrates. Several transcript variants, some protein-coding and some not, have been found for this gene. [provided by RefSeq, Mar 2012].

References

Further reading