DGKQ

DGKQ
Identifiers
Aliases	DGKQ, DAGK, DAGK4, DAGK7, diacylglycerol kinase theta
External IDs	MGI: 102918 HomoloGene: 20352 GeneCards: DGKQ
Gene location (Human)
Chr.	Chromosome 4 (human)[1]
End	986,895 bp[1]
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)[2]
End	108,669,672 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• transferase activity; • nucleotide binding; • phospholipase binding; • activating transcription factor binding; • metal ion binding; • kinase activity; • kinase binding; • protein binding; • ATP binding; • diacylglycerol kinase activity; • transmembrane receptor protein tyrosine kinase activator activity; • NAD+ kinase activity;
Cellular component	• cytoplasm; • cytosol; • nuclear speck; • membrane; • plasma membrane; • cytoskeleton; • cell nucleus; • endosome; • vesicle membrane; • nuclear matrix; • presynapse; • postsynapse; • glutamatergic synapse;
Biological process	• G-protein coupled receptor signaling pathway; • thrombin-activated receptor signaling pathway; • response to ATP; • intracellular signal transduction; • phosphorylation; • regulation of transcription from RNA polymerase II promoter; • protein kinase C signaling; • platelet activation; • protein kinase C-activating G-protein coupled receptor signaling pathway; • signal transduction; • glycerolipid metabolic process; • diacylglycerol metabolic process; • lipid phosphorylation; • regulation of gluconeogenesis; • phosphatidic acid biosynthetic process; • activation of transmembrane receptor protein tyrosine kinase activity; • regulation of G-protein coupled receptor protein signaling pathway; • positive regulation of gene expression; • negative regulation of gene expression; • negative regulation of peptidyl-threonine phosphorylation; • peptidyl-serine phosphorylation; • cAMP-mediated signaling; • positive regulation of peptidyl-tyrosine phosphorylation; • response to cAMP; • regulation of cholesterol metabolic process; • regulation of TORC1 signaling; • regulation of cortisol biosynthetic process; • regulation of progesterone biosynthetic process; • metabolism; • regulation of synaptic vesicle endocytosis;
	Sources:Amigo / QuickGO
Orthologs
	1609
	110524
	ENSG00000145214
	ENSMUSG00000004815
	P52824
	Q6P5E8
	NM_001347
	NM_199011; NM_001357029
	NP_001338
	NP_950176; NP_001343958
	Wikidata
View/Edit Human	View/Edit Mouse

Diacylglycerol kinase theta is an enzyme that in humans is encoded by the DGKQ gene.^[5]^[6]^[7]

The protein encoded by this gene contains three cysteine-rich domains, a proline-rich region, and a pleckstrin homology domain with an overlapping Ras-associating domain. It is localized in the speckle domains of the nucleus, and mediates the regeneration of phosphatidylinositol (PI) from diacylglycerol in the PI-cycle during cell signal transduction.^[7]

Interactions

DGKQ has been shown to interact with RHOA.^[8]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000145214 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000004815 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Endele S, Zabel B, Winterpacht A (Jun 1996). "Assignment of the human diacylglycerol kinase 4 (DAGK4) gene to chromosome 4p16.3". Genomics. 33 (1): 145–6. doi:10.1006/geno.1996.0174. PMID 8617502.
↑ Houssa B, Schaap D, van der Wal J, Goto K, Kondo H, Yamakawa A, Shibata M, Takenawa T, van Blitterswijk WJ (May 1997). "Cloning of a novel human diacylglycerol kinase (DGKtheta) containing three cysteine-rich domains, a proline-rich region, and a pleckstrin homology domain with an overlapping Ras-associating domain". J Biol Chem. 272 (16): 10422–8. doi:10.1074/jbc.272.16.10422. PMID 9099683.
1 2 "Entrez Gene: DGKQ diacylglycerol kinase, theta 110kDa".
↑ Houssa, B; de Widt J; Kranenburg O; Moolenaar W H; van Blitterswijk W J (Mar 1999). "Diacylglycerol kinase theta binds to and is negatively regulated by active RhoA". J. Biol. Chem. UNITED STATES. 274 (11): 6820–2. doi:10.1074/jbc.274.11.6820. ISSN 0021-9258. PMID 10066731.

Sakane F, Kanoh H (1998). "Molecules in focus: diacylglycerol kinase". Int. J. Biochem. Cell Biol. 29 (10): 1139–43. doi:10.1016/S1357-2725(97)00037-X. PMID 9438377.
Li D, Urs AN, Allegood J, et al. (2008). "Cyclic AMP-Stimulated Interaction between Steroidogenic Factor 1 and Diacylglycerol Kinase θ Facilitates Induction of CYP17". Mol. Cell. Biol. 27 (19): 6669–85. doi:10.1128/MCB.00355-07. PMC 2099220. PMID 17664281.
van Baal J, de Widt J, Divecha N, van Blitterswijk WJ (2005). "Translocation of diacylglycerol kinase theta from cytosol to plasma membrane in response to activation of G protein-coupled receptors and protein kinase C". J. Biol. Chem. 280 (11): 9870–8. doi:10.1074/jbc.M409301200. PMID 15632189.
Tabellini G, Bortul R, Santi S, et al. (2003). "Diacylglycerol kinase-theta is localized in the speckle domains of the nucleus". Exp. Cell Res. 287 (1): 143–54. doi:10.1016/S0014-4827(03)00115-0. PMID 12799190.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Houssa B, de Widt J, Kranenburg O, et al. (1999). "Diacylglycerol kinase theta binds to and is negatively regulated by active RhoA". J. Biol. Chem. 274 (11): 6820–2. doi:10.1074/jbc.274.11.6820. PMID 10066731.
Sakane F, Imai S, Kai M, et al. (1996). "Molecular cloning of a novel diacylglycerol kinase isozyme with a pleckstrin homology domain and a C-terminal tail similar to those of the EPH family of protein-tyrosine kinases". J. Biol. Chem. 271 (14): 8394–401. doi:10.1074/jbc.271.14.8394. PMID 8626538.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000145214 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000004815 - Ensembl, May 2017

[3] "Human PubMed Reference:".

[4] "Mouse PubMed Reference:".

[pmid8617502-5] Endele S, Zabel B, Winterpacht A (Jun 1996). "Assignment of the human diacylglycerol kinase 4 (DAGK4) gene to chromosome 4p16.3". Genomics. 33 (1): 145–6. doi:10.1006/geno.1996.0174. PMID 8617502.

[pmid9099683-6] Houssa B, Schaap D, van der Wal J, Goto K, Kondo H, Yamakawa A, Shibata M, Takenawa T, van Blitterswijk WJ (May 1997). "Cloning of a novel human diacylglycerol kinase (DGKtheta) containing three cysteine-rich domains, a proline-rich region, and a pleckstrin homology domain with an overlapping Ras-associating domain". J Biol Chem. 272 (16): 10422–8. doi:10.1074/jbc.272.16.10422. PMID 9099683.

[entrez-7] 1 2 "Entrez Gene: DGKQ diacylglycerol kinase, theta 110kDa".

[pmid10066731-8] Houssa, B; de Widt J; Kranenburg O; Moolenaar W H; van Blitterswijk W J (Mar 1999). "Diacylglycerol kinase theta binds to and is negatively regulated by active RhoA". J. Biol. Chem. UNITED STATES. 274 (11): 6820–2. doi:10.1074/jbc.274.11.6820. ISSN 0021-9258. PMID 10066731.

DGKQ

Interactions

References

Further reading