DGCR5

DGCR5
Identifiers
AliasesDGCR5, LINC00037, NCRNA00037, DiGeorge syndrome critical region gene 5 (non-protein coding), DiGeorge syndrome critical region gene 5
External IDsGeneCards: DGCR5
Gene location (Human)
Chr.Chromosome 22 (human)[1]
Band22q11.21Start18,970,525 bp[1]
End19,031,242 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

26220

n/a

Ensembl

ENSG00000283406

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)Chr 22: 18.97 – 19.03 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

In molecular biology, DiGeorge syndrome critical region gene 5 (non-protein coding), also known as DGCR5, is a long non-coding RNA. In humans, it is located on chromosome 22q11, at the ADU breakpoint associated with DiGeorge syndrome.[3] Its expression is regulated by the transcription factor REST (RE1-Silencing Transcription factor).[4]

See also

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000283406 - Ensembl, May 2017
  2. ↑ "Human PubMed Reference:".
  3. ↑ Sutherland HF, Wadey R, McKie JM, Taylor C, Atif U, Johnstone KA, Halford S, Kim UJ, Goodship J, Baldini A, Scambler PJ (Jul 1996). "Identification of a novel transcript disrupted by a balanced translocation associated with DiGeorge syndrome". American Journal of Human Genetics. 59 (1): 23–31. PMC 1915101. PMID 8659529.
  4. ↑ Johnson R, Teh CH, Jia H, Vanisri RR, Pandey T, Lu ZH, Buckley NJ, Stanton LW, Lipovich L (Jan 2009). "Regulation of neural macroRNAs by the transcriptional repressor REST". Rna. 15 (1): 85–96. doi:10.1261/rna.1127009. PMC 2612765. PMID 19050060.

Further reading

  • Hirosawa M, Nagase T, Murahashi Y, Kikuno R, Ohara O (Feb 2001). "Identification of novel transcribed sequences on human chromosome 22 by expressed sequence tag mapping". DNA Research. 8 (1): 1–9. doi:10.1093/dnares/8.1.1. PMID 11258795.
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