DGAT1

DGAT1
Identifiers
Aliases	DGAT1, ARAT, ARGP1, DGAT, DIAR7, diacylglycerol O-acyltransferase 1
External IDs	MGI: 1333825 HomoloGene: 7688 GeneCards: DGAT1
EC number	2.3.1.76
Gene location (Human)
Chr.	Chromosome 8 (human)[1]
End	144,326,910 bp[1]
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)[2]
End	76,511,953 bp[2]
Gene ontology
Molecular function	• transferase activity; • O-acyltransferase activity; • protein binding; • 2-acylglycerol O-acyltransferase activity; • retinol O-fatty-acyltransferase activity; • transferase activity, transferring acyl groups; • diacylglycerol O-acyltransferase activity;
Cellular component	• integral component of membrane; • endoplasmic reticulum membrane; • membrane; • intracellular membrane-bounded organelle; • endoplasmic reticulum; • plasma membrane; • specific granule membrane;
Biological process	• glycerolipid metabolic process; • retinol metabolic process; • lipid storage; • fatty acid homeostasis; • diacylglycerol metabolic process; • triglyceride biosynthetic process; • very-low-density lipoprotein particle assembly; • long-chain fatty-acyl-CoA metabolic process; • triglyceride metabolic process; • acylglycerol acyl-chain remodeling; • neutrophil degranulation;
	Sources:Amigo / QuickGO
Orthologs
	8694
	13350
	ENSG00000185000; ENSG00000285482
	ENSMUSG00000022555
	O75907
	Q9Z2A7
	NM_012079
	NM_010046
	NP_036211
	NP_034176
	Wikidata
View/Edit Human	View/Edit Mouse

Diacylglycerol O-acyltransferase 1 is an enzyme that in humans is encoded by the DGAT1 gene.^[5]

Function

This gene encodes an multipass transmembrane protein that functions as a key metabolic enzyme. The encoded protein catalyzes the conversion of diacylglycerol and fatty acyl CoA to triacylglycerol. This enzyme can also transfer acyl CoA to retinol. Activity of this protein may be associated with obesity and other metabolic diseases.^[6]

References

1 2 3 ENSG00000285482 GRCh38: Ensembl release 89: ENSG00000185000, ENSG00000285482 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022555 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ "Entrez Gene: Diacylglycerol O-acyltransferase 1". Retrieved 2016-08-28.
↑ Yen CL, Stone SJ, Koliwad S, Harris C, Farese RV (2008). "Thematic review series: glycerolipids. DGAT enzymes and triacylglycerol biosynthesis". Journal of Lipid Research. 49 (11): 2283–301. doi:10.1194/jlr.R800018-JLR200. PMC 3837458. PMID 18757836.

Ludwig EH, Mahley RW, Palaoglu E, Ozbayrakçi S, Balestra ME, Borecki IB, Innerarity TL, Farese RV (July 2002). "DGAT1 promoter polymorphism associated with alterations in body mass index, high density lipoprotein levels and blood pressure in Turkish women". Clinical Genetics. 62 (1): 68–73. doi:10.1034/j.1399-0004.2002.620109.x. PMID 12123490.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[refGRCh38Ensembl-1] 1 2 3 ENSG00000285482 GRCh38: Ensembl release 89: ENSG00000185000, ENSG00000285482 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022555 - Ensembl, May 2017

[3] "Human PubMed Reference:".

[4] "Mouse PubMed Reference:".

[entrez-5] "Entrez Gene: Diacylglycerol O-acyltransferase 1". Retrieved 2016-08-28.

[pmid18757836-6] Yen CL, Stone SJ, Koliwad S, Harris C, Farese RV (2008). "Thematic review series: glycerolipids. DGAT enzymes and triacylglycerol biosynthesis". Journal of Lipid Research. 49 (11): 2283–301. doi:10.1194/jlr.R800018-JLR200. PMC 3837458. PMID 18757836.

DGAT1

Function

See also

References

Further reading