DEFB127

DEFB127
Identifiers
AliasesDEFB127, C20orf73, DEF-27, DEFB-27, DEFB27, bA530N10.2, hBD-27, defensin beta 127
External IDsHomoloGene: 89142 GeneCards: DEFB127
Gene location (Human)
Chr.Chromosome 20 (human)[1]
Band20p13Start157,470 bp[1]
End159,163 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

140850

n/a

Ensembl

ENSG00000088782

n/a

UniProt

Q9H1M4

n/a

RefSeq (mRNA)

NM_139074

n/a

RefSeq (protein)

NP_620713

n/a

Location (UCSC)Chr 20: 0.16 – 0.16 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Beta-defensin 127 is a protein that in humans is encoded by the DEFB127 gene.[3][4]

Defensins are cysteine-rich cationic polypeptides that are important in the immunologic response to invading microorganisms. The protein encoded by this gene is secreted and is a member of the beta defensin protein family. Beta defensin genes are found in several clusters throughout the genome, with this gene mapping to a cluster at 20p13.[4]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000088782 - Ensembl, May 2017
  2. ↑ "Human PubMed Reference:".
  3. ↑ Schutte BC, Mitros JP, Bartlett JA, Walters JD, Jia HP, Welsh MJ, Casavant TL, McCray PB Jr (Feb 2002). "Discovery of five conserved beta -defensin gene clusters using a computational search strategy". Proc Natl Acad Sci U S A. 99 (4): 2129–33. doi:10.1073/pnas.042692699. PMC 122330. PMID 11854508.
  4. 1 2 "Entrez Gene: DEFB127 defensin, beta 127".

Further reading

  • van Wetering S, Sterk PJ, Rabe KF, Hiemstra PS (2000). "Defensins: key players or bystanders in infection, injury, and repair in the lung?". J. Allergy Clin. Immunol. 104 (6): 1131–8. doi:10.1016/S0091-6749(99)70004-7. PMID 10588992.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
  • Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
  • Rodríguez-Jiménez FJ, Krause A, Schulz S, et al. (2003). "Distribution of new human beta-defensin genes clustered on chromosome 20 in functionally different segments of epididymis". Genomics. 81 (2): 175–83. doi:10.1016/S0888-7543(02)00034-4. PMID 12620395.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.


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