DDO (gene)

DDO
Identifiers
AliasesDDO, Ddo, 5330420D20Rik, 5730402C02Rik, AI467244, DASOX, DDO-1, DDO-2, D-aspartate oxidase
External IDsMGI: 1925528 HomoloGene: 101531 GeneCards: DDO
Gene location (Human)
Chr.Chromosome 6 (human)[1]
Band6q21Start110,391,771 bp[1]
End110,415,562 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

8528

70503

Ensembl

ENSG00000203797

ENSMUSG00000063428

UniProt

Q99489

Q922Z0

RefSeq (mRNA)

NM_003649
NM_004032

NM_027442
NM_001316716
NM_001316717
NM_001316718
NM_001316719

RefSeq (protein)

NP_003640
NP_004023

NP_001303645
NP_001303646
NP_001303647
NP_001303648
NP_081718

Location (UCSC)Chr 6: 110.39 – 110.42 MbChr 10: 40.63 – 40.68 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

D-aspartate oxidase is an enzyme that is encoded by the DDO gene.[5][6]

The protein encoded by this gene is a peroxisomal flavoprotein that catalyzes the oxidative deamination of D-aspartate and N-methyl D-aspartate. Flavin adenine dinucleotide or 6-hydroxyflavin adenine dinucleotide can serve as the cofactor in this reaction. Two (or four, according to Q99489) transcript variants encoding different isoforms have been found for this gene.[6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000203797 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000063428 - Ensembl, May 2017
  3. "Human PubMed Reference:".
  4. "Mouse PubMed Reference:".
  5. Setoyama C, Miura R (Jul 1997). "Structural and functional characterization of the human brain D-aspartate oxidase". J Biochem. 121 (4): 798–803. doi:10.1093/oxfordjournals.jbchem.a021655. PMID 9163533.
  6. 1 2 "Entrez Gene: DDO D-aspartate oxidase".

Further reading

  • Barker RF, Hopkinson DA (1977). "The genetic and biochemical properties of the D-amino acid oxidases in human tissues". Ann. Hum. Genet. 41 (1): 27–42. doi:10.1111/j.1469-1809.1977.tb01959.x. PMID 21608.
  • Van Veldhoven PP, Brees C, Mannaerts GP (1991). "D-aspartate oxidase, a peroxisomal enzyme in liver of rat and man". Biochim. Biophys. Acta. 1073 (1): 203–8. doi:10.1016/0304-4165(91)90203-S. PMID 1991137.
  • Nagasaki H (1994). "Gender-related differences of mouse liver D-aspartate oxidase in the activity and response to administration of D-aspartate and peroxisome proliferators". Int. J. Biochem. 26 (3): 415–23. doi:10.1016/0020-711X(94)90062-0. PMID 8187937.
  • Simonic T, Duga S, Negri A, et al. (1997). "cDNA cloning and expression of the flavoprotein D-aspartate oxidase from bovine kidney cortex". Biochem. J. 322 (3): 729–35. PMC 1218248. PMID 9148742.
  • Amery L, Brees C, Baes M, et al. (1999). "C-terminal tripeptide Ser-Asn-Leu (SNL) of human D-aspartate oxidase is a functional peroxisome-targeting signal". Biochem. J. 336 (2): 367–71. doi:10.1042/bj3360367. PMC 1219880. PMID 9820813.
  • Zaar K, Köst HP, Schad A, et al. (2002). "Cellular and subcellular distribution of D-aspartate oxidase in human and rat brain". J. Comp. Neurol. 450 (3): 272–82. doi:10.1002/cne.10320. PMID 12209855.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.


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