DAP (gene)

DAP
Identifiers
AliasesDAP, death associated protein
External IDsMGI: 1918190 HomoloGene: 3235 GeneCards: DAP
Gene location (Human)
Chr.Chromosome 5 (human)[1]
Band5p15.2Start10,679,230 bp[1]
End10,761,272 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

1611

223453

Ensembl

ENSG00000112977

ENSMUSG00000039168

UniProt

P51397

Q91XC8

RefSeq (mRNA)

NM_004394
NM_001291963

NM_146057

RefSeq (protein)

NP_001278892
NP_004385

NP_666169

Location (UCSC)Chr 5: 10.68 – 10.76 MbChr 15: 31.22 – 31.27 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Death-associated protein 1 is a protein that in humans is encoded by the DAP gene.[5][6][7]

DAP gene encodes a basic, proline-rich, 15-kD protein. Death-associated protein acts as a positive mediator of programmed cell death that is induced by interferon-gamma.[7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000112977 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000039168 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Feinstein E, Druck T, Kastury K, Berissi H, Goodart SA, Overhauser J, Kimchi A, Huebner K (Feb 1996). "Assignment of DAP1 and DAPK--genes that positively mediate programmed cell death triggered by IFN-gamma--to chromosome regions 5p12.2 and 9q34.1, respectively". Genomics. 29 (1): 305–7. doi:10.1006/geno.1995.1255. PMID 8530096.
  6. ↑ Deiss LP, Feinstein E, Berissi H, Cohen O, Kimchi A (Feb 1995). "Identification of a novel serine/threonine kinase and a novel 15-kD protein as potential mediators of the gamma interferon-induced cell death". Genes Dev. 9 (1): 15–30. doi:10.1101/gad.9.1.15. PMID 7828849.
  7. 1 2 "Entrez Gene: DAP death-associated protein".

Further reading

  • Levy-Strumpf N, Kimchi A (1999). "Death associated proteins (DAPs): from gene identification to the analysis of their apoptotic and tumor suppressive functions". Oncogene. 17 (25): 3331–40. doi:10.1038/sj.onc.1202588. PMID 9916995.
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
  • Zougman A, Wiśniewski JR (2006). "Beyond linker histones and high mobility group proteins: global profiling of perchloric acid soluble proteins". J. Proteome Res. 5 (4): 925–34. doi:10.1021/pr050415p. PMID 16602700.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
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