DACH2

DACH2
Identifiers
AliasesDACH2, dachshund family transcription factor 2
External IDsMGI: 1890446 HomoloGene: 33472 GeneCards: DACH2
Gene location (Human)
Chr.X chromosome (human)[1]
BandXq21.2Start86,148,458 bp[1]
End86,832,604 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

117154

93837

Ensembl

ENSG00000126733

ENSMUSG00000025592

UniProt

Q96NX9

Q925Q8

RefSeq (mRNA)

NM_001139514
NM_001139515
NM_053281

NM_001142570
NM_001289732
NM_001289733
NM_001289734
NM_033605

RefSeq (protein)

NP_001132986
NP_001132987
NP_444511

NP_001136042
NP_001276661
NP_001276662
NP_001276663
NP_291083

Location (UCSC)Chr X: 86.15 – 86.83 MbChr X: 113.3 – 113.84 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Dachshund homolog 2 is a protein that in humans is encoded by the DACH2 gene.[5]

Function

This gene is one of two genes which encode a protein similar to the Drosophila protein dachshund, a transcription factor involved in cell fate determination in the eye, limb and genital disc of the fly. The encoded protein contains two characteristic dachshund domains: an N-terminal domain responsible for DNA binding and a C-terminal domain responsible for protein-protein interactions. This gene is located on the X chromosome and is subject to inactivation by DNA methylation. The encoded protein may be involved in regulation of organogenesis and myogenesis, and may play a role in premature ovarian failure.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000126733 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025592 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Multiple transcript variants encoding different isoforms have been found for this gene. "Entrez Gene: Dachshund homolog 2 (Drosophila)". Retrieved 2012-04-15.

Further reading

  • Bione S, Rizzolio F, Sala C, Ricotti R, Goegan M, Manzini MC, Battaglia R, Marozzi A, Vegetti W, Dalprà L, Crosignani PG, Ginelli E, Nappi R, Bernabini S, Bruni V, Torricelli F, Zuffardi O, Toniolo D (Dec 2004). "Mutation analysis of two candidate genes for premature ovarian failure, DACH2 and POF1B". Human Reproduction. 19 (12): 2759–66. doi:10.1093/humrep/deh502. PMID 15459172.
  • Poulin F, Nobrega MA, Plajzer-Frick I, Holt A, Afzal V, Rubin EM, Pennacchio LA (Jun 2005). "In vivo characterization of a vertebrate ultraconserved enhancer" (Submitted manuscript). Genomics. 85 (6): 774–81. doi:10.1016/j.ygeno.2005.03.003. PMID 15885503.
  • Davis RJ, Shen W, Sandler YI, Heanue TA, Mardon G (Apr 2001). "Characterization of mouse Dach2, a homologue of Drosophila dachshund". Mechanisms of Development. 102 (1–2): 169–79. doi:10.1016/s0925-4773(01)00307-0. PMID 11287190.
  • Aikawa Y, Nguyen LA, Isono K, Takakura N, Tagata Y, Schmitz ML, Koseki H, Kitabayashi I (Sep 2006). "Roles of HIPK1 and HIPK2 in AML1- and p300-dependent transcription, hematopoiesis and blood vessel formation". The EMBO Journal. 25 (17): 3955–65. doi:10.1038/sj.emboj.7601273. PMC 1560355. PMID 16917507.
  • Prueitt RL, Chen H, Barnes RI, Zinn AR (2002). "Most X;autosome translocations associated with premature ovarian failure do not interrupt X-linked genes". Cytogenetic and Genome Research. 97 (1–2): 32–8. doi:10.1159/000064052. PMID 12438735.


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