Cornea verticillata

Cornea verticillata
Cornea verticillata: A bilateral, whorl-like corneal pattern of cream colored lines in a patient with Fabry disease.


Cornea verticillata, also called Fleischer vortex,[1] vortex keratopathy or whorl keratopathy, is a condition characterised by corneal deposits at the level of the basal epithelium forming a faint golden-brown whorl pattern.[2] It is seen in Fabry disease or in case of prolonged amiodarone intake.[3]

Causes

Amiodarone

Fabry’s disease

Chloroquine

Hydroxychloroquine

Indomethacin

Phenothiazines etc.

Presentation

No ocular complaints or visual difficulty is usually present.[3][4]

Pathophysiology

This keratopathy is probably a type of drug-induced lipidosis.[3]

References

  1. ↑ "Definition: 'Cornea Verticillata'". MediLexicon. Retrieved 29 November 2013.
  2. ↑ van der Tol, Linda; Sminia, Marije L; Hollak, Carla E M; Biegstraaten, Marieke (2016). "Cornea verticillata supports a diagnosis of Fabry disease in non-classical phenotypes: results from the Dutch cohort and a systematic review". British Journal of Ophthalmology. 100 (1): 3–8. doi:10.1136/bjophthalmol-2014-306433. ISSN 0007-1161.
  3. 1 2 3 Chew, E; Ghosh, M; McCulloch, C (June 1982). "Amiodarone-induced cornea verticillata". Canadian journal of ophthalmology. Journal canadien d'ophtalmologie. 17 (3): 96–9. PMID 7116220.
  4. ↑ Graff, Jordan M. (February 21, 2005). "Verticillata". University of Iowa Health Care, Ophthalmology and Visual Sciences. Retrieved 29 November 2013.
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