Clazakizumab

Clazakizumab
Monoclonal antibody
Type Whole antibody
Source Humanized
Target IL6
Clinical data
Synonyms ALD518, BMS-945429
Routes of
administration		 infusion
ATC code
  • none
Legal status
Legal status
  • investigational
Identifiers
CAS Number
ChemSpider
  • none
KEGG
Chemical and physical data
Formula C6426H9972N1724O2032S42
Molar mass 145.2 kg/mol

Clazakizumab (formerly ALD518 and BMS-945429), an investigational drug, is a aglycosylated, humanized rabbit monoclonal antibody against interleukin-6.[1] Clazakizumab was developed by Bristol Myers Squib and Alder Biopharmaceuticals. A preliminary randomized, double-blind, placebo-controlled, phase 2 dose-ranging study of clazakizumab in psoriatic arthritis patients, funded by the manufacturer, suggested that clazakizumab may be an effective treatment option for musculoskeletal aspects of psoriatic arthritis; however, the antibody lacked a dose-response effect.[2]

See also

References

  1. ↑ Handbook of Therapeutic Antibodies, Volume 2. Wiley Blackwell. 2007. p. 987. Retrieved January 23, 2017.
  2. ↑ Mease PJ, Gottlieb AB, et al. (September 2016). "The efficacy and safety of clazakizumab, an anti-interleukin-6 monoclonal antibody, in a phase IIb study of adults with active psoriatic arthritis". Arthritis Rheumatol. 68 (9): 2163–73. doi:10.1002/art.39700.
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