Christian Hamel

Christian Hamel (4 October 1955 – 15 August 2017) was a French Professor at the Institute for Neurosciences of Montpellier, Hôpital Saint Eloi (INM) research unit INSERM 583 of the University. He studied transduction, integration and disorders of sensory and motor systems with the ultimate goal of finding treatments for degeneration of the retina and optic nerve.[1]

Hamel discovered and described in 1993 the RPE65 protein.[2][3] Retinal pigment epithelium-specific 65 kDa protein is an enzyme in the vertebral visual pigment.[4] The next year he mapped the RPE65 gene to human chromosome 1 (mouse chromosome 3) and refined it to 1p31 by fluorescense in situ hybridization.[5] His research interests were to find the causes of inherited diseases of the retina and optic nerve.[6]

References

  1. ↑ "Monperrus Clémentine, "A Montpellier, les 10 chercheurs les plus en pointe", L'Express, 12 octobre 2011 htpp://lexpansion.lexpress.fr/actualite-economique/a-montpellier-les-10-chercheurs-les-plus-en-pointe 1443219.html
  2. ↑ "Hamel C.P. et al., "A developmentally regulated microsomal protein specific for the pigment epithelium of the vertebrate retina", Journal of Neuroscience Research, 1993; 34 (4), p. 414-425" [PubMed: 8474143]
  3. ↑ Hamel C.P. et al., "Molecular cloning and expression of RPE65, a novel retinal pigment epithelium-specific microsomal protein that is posttranscriptionally regulated in vitro", J Biol Chem 268 (21), 1993, p. 15751-15757 [PubMed: 8340400]
  4. ↑ Xue Cai et al., "RPE65: Role in the visual cycle, human retinal disease, and gene therapy", Ophthamic Genet., 2009; 30 (2), p. 57-65 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2821785/pdf/nihms168011.pdf
  5. ↑ Hamel C.P. et al., "The gene for the retinal pigment epithelium-specific protein RPE65 is localized to human 1p31 and mouse 3.", Genomics 20 (3), 1994, p. 508-512 [PubMed: 208034329]
  6. ↑ European Vision Institute EEIG, Belgium: CV of researcher htpp://www.vision-research.eu/index.php?id=210
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.