ChGn

CSGALNACT1
Identifiers
Aliases	CSGALNACT1, CSGalNAcT-1, ChGn, beta4GalNAcT, chondroitin sulfate N-acetylgalactosaminyltransferase 1
External IDs	MGI: 2442354 HomoloGene: 23099 GeneCards: CSGALNACT1
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)[1]
End	68,735,146 bp[1]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• transferase activity; • glucuronosyltransferase activity; • metal ion binding; • peptidoglycan glycosyltransferase activity; • glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity; • acetylgalactosaminyltransferase activity; • glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity;
Cellular component	• integral component of membrane; • integral component of Golgi membrane; • Golgi apparatus; • membrane; • Golgi membrane; • intracellular; • Golgi cisterna membrane;
Biological process	• UDP-N-acetylgalactosamine metabolic process; • heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process; • heparin biosynthetic process; • cell recognition; • chondroitin sulfate biosynthetic process; • anatomical structure morphogenesis; • extracellular matrix organization; • endochondral ossification; • UDP-glucuronate metabolic process; • nervous system development; • cartilage development; • chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process; • chondroitin sulfate proteoglycan biosynthetic process; • cell proliferation; • proteoglycan biosynthetic process; • dermatan sulfate proteoglycan biosynthetic process; • chondroitin sulfate metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	55790
	234356
	n/a
	ENSMUSG00000036356
	Q8TDX6
	Q8BJQ9
	NM_001130518; NM_018371
	NM_001252623; NM_172753; NM_001364256
NP_001123990; NP_060841; NP_001341405; NP_001341406; NP_001341409;
	NP_001341410; NP_001341412; NP_001341413; NP_001341414; NP_001341416; NP_001341417; NP_001341418; NP_001341419; NP_001341420; NP_001341421; NP_001341423; NP_001341424; NP_001341425; NP_001341426; NP_001341427; NP_001341428; NP_001341404
	NP_001239552; NP_766341; NP_001351185
	Wikidata
View/Edit Human	View/Edit Mouse

Chondroitin sulfate N-acetylgalactosaminyltransferase 1 is an enzyme that in humans is encoded by the CSGALNACT1 gene.^[4]^[5]^[6]

References

1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000036356 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Sakai K, Kimata K, Sato T, Gotoh M, Narimatsu H, Shinomiya K, Watanabe H (Feb 2007). "Chondroitin sulfate N-acetylgalactosaminyltransferase-1 plays a critical role in chondroitin sulfate synthesis in cartilage". The Journal of Biological Chemistry. 282 (6): 4152–61. doi:10.1074/jbc.M606870200. PMID 17145758.
↑ Sato T, Gotoh M, Kiyohara K, Akashima T, Iwasaki H, Kameyama A, Mochizuki H, Yada T, Inaba N, Togayachi A, Kudo T, Asada M, Watanabe H, Imamura T, Kimata K, Narimatsu H (Jan 2003). "Differential roles of two N-acetylgalactosaminyltransferases, CSGalNAcT-1, and a novel enzyme, CSGalNAcT-2. Initiation and elongation in synthesis of chondroitin sulfate". The Journal of Biological Chemistry. 278 (5): 3063–71. doi:10.1074/jbc.M208886200. PMID 12446672.
↑ "Entrez Gene: ChGn chondroitin beta1,4 N-acetylgalactosaminyltransferase".

Gotoh M, Sato T, Akashima T, Iwasaki H, Kameyama A, Mochizuki H, Yada T, Inaba N, Zhang Y, Kikuchi N, Kwon YD, Togayachi A, Kudo T, Nishihara S, Watanabe H, Kimata K, Narimatsu H (Oct 2002). "Enzymatic synthesis of chondroitin with a novel chondroitin sulfate N-acetylgalactosaminyltransferase that transfers N-acetylgalactosamine to glucuronic acid in initiation and elongation of chondroitin sulfate synthesis". The Journal of Biological Chemistry. 277 (41): 38189–96. doi:10.1074/jbc.M203619200. PMID 12163485.
Uyama T, Kitagawa H, Tamura Ji J, Sugahara K (Mar 2002). "Molecular cloning and expression of human chondroitin N-acetylgalactosaminyltransferase: the key enzyme for chain initiation and elongation of chondroitin/dermatan sulfate on the protein linkage region tetrasaccharide shared by heparin/heparan sulfate". The Journal of Biological Chemistry. 277 (11): 8841–6. doi:10.1074/jbc.M111434200. PMID 11788602.
Kitagawa H, Uyama T, Sugahara K (Oct 2001). "Molecular cloning and expression of a human chondroitin synthase". The Journal of Biological Chemistry. 276 (42): 38721–6. doi:10.1074/jbc.M106871200. PMID 11514575.

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[refGRCm38Ensembl-1] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000036356 - Ensembl, May 2017

[2] "Human PubMed Reference:".

[3] "Mouse PubMed Reference:".

[pmid17145758-4] Sakai K, Kimata K, Sato T, Gotoh M, Narimatsu H, Shinomiya K, Watanabe H (Feb 2007). "Chondroitin sulfate N-acetylgalactosaminyltransferase-1 plays a critical role in chondroitin sulfate synthesis in cartilage". The Journal of Biological Chemistry. 282 (6): 4152–61. doi:10.1074/jbc.M606870200. PMID 17145758.

[pmid12446672-5] Sato T, Gotoh M, Kiyohara K, Akashima T, Iwasaki H, Kameyama A, Mochizuki H, Yada T, Inaba N, Togayachi A, Kudo T, Asada M, Watanabe H, Imamura T, Kimata K, Narimatsu H (Jan 2003). "Differential roles of two N-acetylgalactosaminyltransferases, CSGalNAcT-1, and a novel enzyme, CSGalNAcT-2. Initiation and elongation in synthesis of chondroitin sulfate". The Journal of Biological Chemistry. 278 (5): 3063–71. doi:10.1074/jbc.M208886200. PMID 12446672.

[entrez-6] "Entrez Gene: ChGn chondroitin beta1,4 N-acetylgalactosaminyltransferase".

ChGn

References

Further reading